DegronMD

Uniprot ID: Q8N387

Source protein: Mucin-15

Source gene: MUC15

Class: LIG_APCC_ABBA_1

Location: 201:206

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.943

ASA_SCORE: 104.7167

COIL: 0.8622

CONS_SCORE: 0.6269

DSS_SCORE: 0.4965

HELIX: 0.0635

FCONS_SCORE: 0.8949

RIG_SCORE: 0.7856

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S191G	TCGA-AA-3864	COAD	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.0556
p.S191G	DO8490	COAD	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.0556
p.S196I	TCGA-AX-A06F	UCEC	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.S196I	DO41752	UCEC	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.V195I	TCGA-DF-A2KV	UCEC	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.1667
p.V195I	DO219771	UCEC	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1667
p.P209T	TCGA-EE-A183	SKCM	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.25
p.P209T	DO37715	SKCM	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.25
p.G216R	TCGA-EJ-8474	PRAD	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.0556
p.G216R	DO48537	PRAD	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.0556
p.P205L	TCGA-YG-AA3N	SKCM	TCGA	FTPYQE	LIG_APCC_ABBA_1	0.7582
p.P205L	DO51298	SKCM	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.7582
p.I211T	DO228483	BRCA	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	DO229010	COCA	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	DO230659	LAML	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	DO231140	LAML	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00586	Hepatocellular Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00565	Oral Cavity Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00352	Ovarian Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00491	Thyroid Gland Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00602	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00463	T-Lymphoblastic Leukemia	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01144	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00356	Non-Small Cell Lung Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00533	Pancreatic Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01196	Hepatocellular Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00351	Oral Cavity Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00299	Other Sarcomas	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00580	Acute Myeloid Leukemia	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01608	Endometrial Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01612	Endometrial Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01335	Kidney Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01526	Mesothelioma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00169	Head and Neck Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01770	Gastric Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM00008	Ovarian Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.I211T	SIDM01454	Kidney Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1944
p.P205Q	DO229026	LICA	ICGC	FTPYQE	LIG_APCC_ABBA_1	0.7035
p.V212M	SIDM02012	Colorectal Carcinoma	GDSC	FTPYQE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FTPYQE

Degron related mutations and impact score

Drug responses associated with MUC15 mutations

All proteins holding degron of FTPYQE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N387	Mucin-15	LIG_APCC_ABBA_1	201:206	FTPYQE	APC,CDC20,FZR1	0.943	More...