DegronMD - O94788(ALDH1A2)

FUNCTION: Converts retinaldehyde to retinoic acid (PubMed:29240402). Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal. Displays complete lack of activity with citral (By similarity). {ECO:0000250|UniProtKB:Q63639, ECO:0000269|PubMed:29240402}.

GO - Biological processes (BP): 9-cis-retinoic acid biosynthetic process [GO:0042904]; blood vessel development [GO:0001568]; cardiac muscle tissue development [GO:0048738]; cellular response to retinoic acid [GO:0071300]; determination of bilateral symmetry [GO:0009855]; embryonic camera-type eye development [GO:0031076]; embryon... View more >>

GO - Molecular function (MF): 3-chloroallyl aldehyde dehydrogenase activity [GO:0004028]; aldehyde dehydrogenase (NAD+) activity [GO:0004029]; retinal binding [GO:0016918]; retinal dehydrogenase activity [GO:0001758]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; perinuclear region of cytoplasm [GO:0048471]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S29F	WM793B	skin	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7982
p.S29F	HTC-C3	thyroid	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7982
p.P31A	TCGA-CV-6938	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7503
p.P31A	DO14462	HNSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7503
p.G34E	DO222908	MELA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7199
p.A32T	DO9010	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7139
p.A32T	DO50970	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7139
p.P31T	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7031
p.P31S	DO233903	GACA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.6752
p.S22L	TCGA-DK-A6B5	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	TCGA-G2-A3IE	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	DO48551	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	DO767	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.L33I	DO229027	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.6063
p.S28P	TCGA-VQ-AA6D	STAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.5641
p.S28P	DO222392	STAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.5641
p.P39T	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation substituting flanking lysine	0.3056
p.L25V	TCGA-DR-A0ZM	CESC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2778
p.L25V	DO6254	CESC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2778
p.H24R	TCGA-CV-5434	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25

Showing 1 to 20 of 49 entries

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Kaplan plot for ALDH1A2 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALDH1A2

UniProt ID: O94788

Entrez ID: 8854

Protein name: Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALDH1A2 in