DegronMD - O94788(ALDH1A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A18D	TCGA-56-8308	LUSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18D	DO219140	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	TCGA-56-8308	LUSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	TCGA-AP-A0LM	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	TCGA-AP-A1DV	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	TCGA-D5-6928	COAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	DO7776	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	DO50382	ESAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	DO219140	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	DO43306	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A18T	DO43186	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0833
p.A21V	TCGA-AA-3492	COAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1667
p.A21V	DO8224	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1667
p.H24R	TCGA-CV-5434	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.H24R	DO14358	HNSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.P31A	TCGA-CV-6938	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7503
p.P31A	DO14462	HNSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7503
p.H24L	TCGA-DI-A0WH	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.H24L	DO43843	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.S22L	TCGA-DK-A6B5	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	TCGA-G2-A3IE	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	DO48551	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.S22L	DO767	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation blocking phosphorylation signal	0.6389
p.L25V	TCGA-DR-A0ZM	CESC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2778
p.L25V	DO6254	CESC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2778
p.Y37C	TCGA-DX-A1KX	SARC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.Y37C	DO219946	SARC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.25
p.S28P	TCGA-VQ-AA6D	STAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.5641
p.S28P	DO222392	STAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.5641
p.L23R	TCGA-XF-A9ST	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2222
p.L23R	DO223599	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.2222
p.I40N	TCGA-XP-A8T6	ESCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1667
p.A32T	DO9010	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7139
p.A32T	DO50970	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7139
p.D44H	DO10639	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0556
p.P31S	DO233903	GACA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.6752
p.L33I	DO229027	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.6063
p.D44E	DO229009	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0556
p.Q41R	DO45382	LUAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1389
p.Q41E	DO219209	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1389
p.G34E	DO222908	MELA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7199
p.N19T	DO36556	READ	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1111
p.A17T	SIDM00929	Chondrosarcoma	GDSC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0556
p.A17T	SIDM01613	Colorectal Carcinoma	GDSC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.0556
p.S29F	WM793B	skin	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7982
p.S29F	HTC-C3	thyroid	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7982
p.P39T	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation substituting flanking lysine	0.3056
p.P31T	RPMI-8866	haematopoietic and lymphoid tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation altering degron motif	0.7031
p.D20Y	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	27:34	Mutation rewiring degron network	0.1389

Kaplan plot for ALDH1A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALDH1A2

UniProt ID: O94788

Entrez ID: 8854

Protein name: Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II))

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALDH1A2 in