DegronMD

Uniprot ID: O94788

Source protein: Retinal dehydrogenase 2

Source gene: ALDH1A2

Class: DEG_SCF_FBW7_2

Location: 27:34

E3 ligase: FBXW7

DEGRON score: 0.7248

ASA_SCORE: 87.7125

COIL: 0.914

CONS_SCORE: 0.3537

DSS_SCORE: 0.1964

HELIX: 0.0441

FCONS_SCORE: 0.7975

RIG_SCORE: 0.7417

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A18D	TCGA-56-8308	LUSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18D	DO219140	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	TCGA-56-8308	LUSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	TCGA-AP-A0LM	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	TCGA-AP-A1DV	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	TCGA-D5-6928	COAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	DO7776	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	DO50382	ESAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	DO219140	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	DO43306	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A18T	DO43186	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0833
p.A21V	TCGA-AA-3492	COAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.1667
p.A21V	DO8224	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.1667
p.H24R	TCGA-CV-5434	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.H24R	DO14358	HNSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.P31A	TCGA-CV-6938	HNSC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.7503
p.P31A	DO14462	HNSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.7503
p.H24L	TCGA-DI-A0WH	UCEC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.H24L	DO43843	UCEC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.S22L	TCGA-DK-A6B5	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.6389
p.S22L	TCGA-G2-A3IE	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.6389
p.S22L	DO48551	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.6389
p.S22L	DO767	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.6389
p.L25V	TCGA-DR-A0ZM	CESC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.2778
p.L25V	DO6254	CESC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.2778
p.Y37C	TCGA-DX-A1KX	SARC	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.Y37C	DO219946	SARC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.25
p.S28P	TCGA-VQ-AA6D	STAD	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.5641
p.S28P	DO222392	STAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.5641
p.L23R	TCGA-XF-A9ST	BLCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.2222
p.L23R	DO223599	BLCA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.2222
p.I40N	TCGA-XP-A8T6	ESCA	TCGA	PSPTPNLE	DEG_SCF_FBW7_2	0.1667
p.A32T	DO9010	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.7139
p.A32T	DO50970	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.7139
p.D44H	DO10639	COAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0556
p.P31S	DO233903	GACA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.6752
p.L33I	DO229027	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.6063
p.D44E	DO229009	LICA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.0556
p.Q41R	DO45382	LUAD	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.1389
p.Q41E	DO219209	LUSC	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.1389
p.G34E	DO222908	MELA	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.7199
p.N19T	DO36556	READ	ICGC	PSPTPNLE	DEG_SCF_FBW7_2	0.1111
p.A17T	SIDM00929	Chondrosarcoma	GDSC	PSPTPNLE	DEG_SCF_FBW7_2	0.0556
p.A17T	SIDM01613	Colorectal Carcinoma	GDSC	PSPTPNLE	DEG_SCF_FBW7_2	0.0556
p.S29F	WM793B	skin	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	0.7982
p.S29F	HTC-C3	thyroid	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	0.7982
p.P39T	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	0.3056
p.P31T	RPMI-8866	haematopoietic_and_lymphoid_tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	0.7031
p.D20Y	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PSPTPNLE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSPTPNLE

Degron related mutations and impact score

Drug responses associated with ALDH1A2 mutations

All proteins holding degron of PSPTPNLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94788	Retinal dehydrogenase 2	DEG_SCF_FBW7_2	27:34	PSPTPNLE	FBXW7	0.7248	More...