DegronMD - O94811(TPPP)

TPPP

UniProt ID: O94811

Entrez ID: 11076

Protein name: Tubulin polymerization-promoting protein (TPPP) (EC 3.6.5.-) (25 kDa brain-specific protein) (TPPP/p25) (p24) (p25-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L48F	TCGA-99-7458	LUAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.L48F	DO25416	LUAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.A66T	TCGA-AP-A059	UCEC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.A66T	DO50809	LIRI	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.A66T	DO41361	UCEC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.A54T	TCGA-CG-5721	STAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.A54T	DO38192	STAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.A50V	TCGA-CM-5861	COAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1389
p.A50V	DO7918	COAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1389
p.E70K	TCGA-EE-A29E	SKCM	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1389
p.E70K	DO37831	SKCM	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.1389
p.A64V	TCGA-EE-A2MU	SKCM	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.A64V	DO37436	SKCM	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.H72Y	TCGA-IB-7651	PAAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.H72Y	DO46657	PAAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.G73D	TCGA-QF-A5YS	UCEC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0556
p.G73D	DO52426	UCEC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0556
p.R56Q	TCGA-VQ-A8DT	STAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.R56Q	DO51751	STAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.H72N	TCGA-WQ-AB4B	LIHC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.H72N	DO52327	LIHC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0833
p.A64T	TCGA-XF-AAMF	BLCA	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.A64T	DO51930	BLCA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.A64T	SIDM00493	Other Solid Cancers	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.A64T	NCI-H292	lung	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.G62R	TCGA-ZN-A9VU	MESO	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6457
p.G73S	DO50442	ESAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.0556
p.A66D	DO228978	LICA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.25
p.R56L	DO232761	PBCA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.3056
p.R65S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.R65S	ACH-002272	Lymphoma	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.R65S	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation rewiring degron network	0.2778
p.V60M	SIDM00783	Colorectal Carcinoma	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6097
p.V60M	ACH-000971	Colon/Colorectal Cancer	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6097
p.V60M	HCT-116	large intestine	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6097
p.D63N	ACH-000984	Endometrial/Uterine Cancer	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	57:63	Mutation altering degron motif	0.6932

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*NOTE: the Kaplan plots were collected from OncoLnc