DegronMD

Uniprot ID: O94811

Source protein: Tubulin polymerization-promoting protein

Source gene: TPPP

Class: LIG_APCC_ABBAyCdc20_2

Location: 57:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7253

ASA_SCORE: 48.9286

COIL: 0.3936

CONS_SCORE: 0.5838

DSS_SCORE: 0.3458

HELIX: 0.5956

FCONS_SCORE: 1.1895

RIG_SCORE: 0.7797

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L48F	TCGA-99-7458	LUAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.L48F	DO25416	LUAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A66T	TCGA-AP-A059	UCEC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A66T	DO50809	LIRI	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A66T	DO41361	UCEC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A54T	TCGA-CG-5721	STAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A54T	DO38192	STAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.A50V	TCGA-CM-5861	COAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A50V	DO7918	COAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E70K	TCGA-EE-A29E	SKCM	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E70K	DO37831	SKCM	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A64V	TCGA-EE-A2MU	SKCM	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A64V	DO37436	SKCM	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H72Y	TCGA-IB-7651	PAAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H72Y	DO46657	PAAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.G73D	TCGA-QF-A5YS	UCEC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.G73D	DO52426	UCEC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R56Q	TCGA-VQ-A8DT	STAD	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R56Q	DO51751	STAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H72N	TCGA-WQ-AB4B	LIHC	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.H72N	DO52327	LIHC	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A64T	TCGA-XF-AAMF	BLCA	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A64T	DO51930	BLCA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A64T	SIDM00493	Other Solid Cancers	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A64T	NCI-H292	lung	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.G62R	TCGA-ZN-A9VU	MESO	TCGA	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.6457
p.G73S	DO50442	ESAD	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.0556
p.A66D	DO228978	LICA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.25
p.R56L	DO232761	PBCA	ICGC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R65S	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R65S	ACH-002272	Lymphoma	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R65S	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V60M	SIDM00783	Colorectal Carcinoma	GDSC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V60M	ACH-000971	Colon/Colorectal Cancer	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.6097
p.V60M	HCT-116	large_intestine	COSMIC	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.6097
p.D63N	ACH-000984	Endometrial/Uterine Cancer	CCLE	RFAVHGD	LIG_APCC_ABBAyCdc20_2	0.6932

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RFAVHGD

Degron related mutations and impact score

Drug responses associated with TPPP mutations

All proteins holding degron of RFAVHGD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94811	Tubulin polymerization-promoting protein	LIG_APCC_ABBAyCdc20_2	57:63	RFAVHGD	APC,CDC20,FZR1	0.7253	More...