DegronMD - O94941(UBOX5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S465Y	TCGA-17-Z043	LUAD	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1389
p.T464A	TCGA-39-5024	LUSC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.T464A	DO27240	LUSC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.S441Y	TCGA-A5-A0G2	UCEC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation blocking phosphorylation signal	0.5278
p.S441Y	DO41235	UCEC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation blocking phosphorylation signal	0.5278
p.W466C	TCGA-UP-A6WW	HNSC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.W466C	DO219092	HNSC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1111
p.G452E	TCGA-W3-A828	SKCM	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	DO51273	SKCM	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	SIDM00002	Neuroblastoma	GDSC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	SIDM01691	Chronic Myelogenous Leukemia	GDSC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	ACH-000321	Leukemia	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	ACH-002340	Neuroblastoma	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.G452E	NBsusSR	autonomic ganglia	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6087
p.E461K	DO465	BLCA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.T446M	DO233279	GACA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation blocking phosphorylation signal	0.6667
p.E443Q	DO228770	LICA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1389
p.P444T	DO229031	LICA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.P444L	DO41572	UCEC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.A447T	ACH-001737	Leukemia	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.25
p.P443S	ACH-002509	Skin Cancer	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1389
p.G451D	SNU-1040	large intestine	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.7198
p.G451S	SW156	kidney	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation altering degron motif	0.6993
p.R464H	NCI-SNU-1	stomach	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.R464H	HCT-15	large intestine	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667
p.R464H	NCI-H1781	lung	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	450:458	Mutation rewiring degron network	0.1667

Kaplan plot for UBOX5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UBOX5

UniProt ID: O94941

Entrez ID: 22888

Protein name: RING finger protein 37 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF37) (U-box domain-containing protein 5) (UbcM4-interacting protein 5) (hUIP5) (Ubiquitin-conjugating enzyme 7-interacting protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UBOX5 in