DegronMD

Uniprot ID: O94941

Source protein: RING finger protein 37

Source gene: UBOX5

Class: DEG_APCC_DBOX_1

Location: 450:458

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6938

ASA_SCORE: 76.0556

COIL: 0.5039

CONS_SCORE: 0.4179

DSS_SCORE: 0.5431

HELIX: 0.4258

FCONS_SCORE: 0.8697

RIG_SCORE: 0.7165

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S465Y	TCGA-17-Z043	LUAD	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	0.1389
p.T464A	TCGA-39-5024	LUSC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.T464A	DO27240	LUSC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.S441Y	TCGA-A5-A0G2	UCEC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	0.5278
p.S441Y	DO41235	UCEC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.5278
p.W466C	TCGA-UP-A6WW	HNSC	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	0.1111
p.W466C	DO219092	HNSC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1111
p.G452E	TCGA-W3-A828	SKCM	TCGA	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	DO51273	SKCM	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	SIDM00002	Neuroblastoma	GDSC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	SIDM01691	Chronic Myelogenous Leukemia	GDSC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	ACH-000321	Leukemia	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	ACH-002340	Neuroblastoma	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.G452E	NBsusSR	autonomic_ganglia	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6087
p.E461K	DO465	BLCA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.25
p.T446M	DO233279	GACA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6667
p.E443Q	DO228770	LICA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1389
p.P444T	DO229031	LICA	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.P444L	DO41572	UCEC	ICGC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.A447T	ACH-001737	Leukemia	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	0.25
p.P443S	ACH-002509	Skin Cancer	CCLE	TRGQLQHLG	DEG_APCC_DBOX_1	0.1389
p.G451D	SNU-1040	large_intestine	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.7198
p.G451S	SW156	kidney	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.6993
p.R464H	NCI-SNU-1	stomach	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.R464H	HCT-15	large_intestine	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667
p.R464H	NCI-H1781	lung	COSMIC	TRGQLQHLG	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94941	RING finger protein 37	DEG_APCC_DBOX_1	450:458	TRGQLQHLG	APC,CDC20,FZR1	0.6938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRGQLQHLG

Degron related mutations and impact score

Drug responses associated with UBOX5 mutations

All proteins holding degron of TRGQLQHLG