DegronMD - O95049(TJP3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R587Q	TCGA-DF-A2KU	UCEC	TCGA	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2222
p.R587Q	SIDM00217	Colorectal Carcinoma	GDSC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2222
p.R587Q	ACH-000999	Colon/Colorectal Cancer	CCLE	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2222
p.R587Q	SNU-1040	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.2222
p.R590C	TCGA-FW-A3R5	SKCM	TCGA	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.R590C	SIDM00217	Colorectal Carcinoma	GDSC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.R590C	SNU-1040	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.R590H	TCGA-G4-6309	COAD	TCGA	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.R590H	ACH-001100		CCLE	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.E607Q	DO220823	BRCA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.1111
p.R595H	DO7810	COAD	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.8244
p.R595L	DO229045	LICA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.8428
p.R595C	DO37406	SKCM	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.8301
p.G593V	DO231221	THCA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7532
p.R592Q	DO223286	UCEC	ICGC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7329
p.G592E	SIDM00853	Other Sarcomas	GDSC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7199
p.G592E	ACH-000835	Sarcoma	CCLE	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7199
p.G592E	GCT	soft tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7199
p.R581C	ACH-000999	Colon/Colorectal Cancer	CCLE	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0556
p.R581C	SNU-1040	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0556
p.A585T	RS4-11	haematopoietic and lymphoid tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation substituting flanking lysine	0.2778
p.G582S	EB-3	haematopoietic and lymphoid tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.0833
p.R590Q	T84	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.R600C	SNU-1040	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.3056
p.G583E	GCT	soft tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.1111
p.G602E	GCT	soft tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation rewiring degron network	0.25
p.R597Q	SNU-1040	large intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	591:599	Mutation altering degron motif	0.7329

Kaplan plot for TJP3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TJP3

UniProt ID: O95049

Entrez ID: 27134

Protein name: Tight junction protein ZO-3 (Tight junction protein 3) (Zona occludens protein 3) (Zonula occludens protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for TJP3 in