DegronMD

Uniprot ID: O95049

Source protein: Tight junction protein ZO-3

Source gene: TJP3

Class: DEG_APCC_DBOX_1

Location: 591:599

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.903

ASA_SCORE: 66.6778

COIL: 0.3188

CONS_SCORE: 0.4231

DSS_SCORE: 0.5626

HELIX: 0.6413

FCONS_SCORE: 1.0046

RIG_SCORE: 0.7401

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R587Q	TCGA-DF-A2KU	UCEC	TCGA	SREDLSALT	DEG_APCC_DBOX_1	0.2222
p.R587Q	SIDM00217	Colorectal Carcinoma	GDSC	SREDLSALT	DEG_APCC_DBOX_1	0.2222
p.R587Q	ACH-000999	Colon/Colorectal Cancer	CCLE	SREDLSALT	DEG_APCC_DBOX_1	0.2222
p.R587Q	SNU-1040	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.2222
p.R590C	TCGA-FW-A3R5	SKCM	TCGA	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.R590C	SIDM00217	Colorectal Carcinoma	GDSC	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.R590C	SNU-1040	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.R590H	TCGA-G4-6309	COAD	TCGA	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.R590H	ACH-001100		CCLE	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.E607Q	DO220823	BRCA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.1111
p.R595H	DO7810	COAD	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.8244
p.R595L	DO229045	LICA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.8428
p.R595C	DO37406	SKCM	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.8301
p.G593V	DO231221	THCA	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.7532
p.R592Q	DO223286	UCEC	ICGC	SREDLSALT	DEG_APCC_DBOX_1	0.7329
p.G592E	SIDM00853	Other Sarcomas	GDSC	SREDLSALT	DEG_APCC_DBOX_1	0.7199
p.G592E	ACH-000835	Sarcoma	CCLE	SREDLSALT	DEG_APCC_DBOX_1	0.7199
p.G592E	GCT	soft_tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.7199
p.R581C	ACH-000999	Colon/Colorectal Cancer	CCLE	SREDLSALT	DEG_APCC_DBOX_1	0.0556
p.R581C	SNU-1040	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.0556
p.A585T	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.2778
p.G582S	EB-3	haematopoietic_and_lymphoid_tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.0833
p.R590Q	T84	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.R600C	SNU-1040	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.3056
p.G583E	GCT	soft_tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.1111
p.G602E	GCT	soft_tissue	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.25
p.R597Q	SNU-1040	large_intestine	COSMIC	SREDLSALT	DEG_APCC_DBOX_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SREDLSALT

Degron related mutations and impact score

Drug responses associated with TJP3 mutations

All proteins holding degron of SREDLSALT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95049	Tight junction protein ZO-3	DEG_APCC_DBOX_1	591:599	SREDLSALT	APC,CDC20,FZR1	0.903	More...