DegronMD - O95069(KCNK2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E392K	TCGA-AC-A23H	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.E392K	TCGA-E6-A2P9	UCEC	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.E392K	TCGA-EE-A29D	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.E392K	DO2401	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.E392K	DO38123	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.E392K	DO43714	UCEC	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.591
p.P398S	TCGA-D3-A8GI	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5641
p.P398S	DO50284	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5641
p.P398S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5641
p.P398S	ACH-000917	Esophageal Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5641
p.P398S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5641
p.H388Y	TCGA-D8-A141	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2222
p.H388Y	DO5514	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2222
p.E403K	TCGA-D8-A1JA	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.25
p.E403K	DO2819	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.25
p.P398L	TCGA-EE-A2GC	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6471
p.P398L	DO37839	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6471
p.L407M	TCGA-KK-A8IH	PRAD	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1389
p.L407M	DO219333	PRAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1389
p.P398H	TCGA-MP-A4TI	LUAD	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6583
p.P398H	DO45420	LUAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6583
p.V395G	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6421
p.V395G	DO50194	LGG	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6421
p.I405F	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1944
p.I405F	DO50194	LGG	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.1944
p.R382K	DO234213	ESAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.E392D	DO45281	LIRI	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.5647
p.R382S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.R382S	ACH-000860	Lung Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.R382S	NCI-H358	lung	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0556
p.S404C	ACH-001390	Breast Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.2222
p.P394S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation altering degron motif	0.6752
p.P383S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	392:400	Mutation rewiring degron network	0.0833

Kaplan plot for KCNK2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNK2

UniProt ID: O95069

Entrez ID: 3776

Protein name: Potassium channel subfamily K member 2 (Outward rectifying potassium channel protein TREK-1) (TREK-1 K(+) channel subunit) (Two pore domain potassium channel TREK-1) (Two pore potassium channel TPKC1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNK2 in