DegronMD

Uniprot ID: O95069

Source protein: Potassium channel subfamily K member 2

Source gene: KCNK2

Class: DEG_APCC_DBOX_1

Location: 392:400

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7946

ASA_SCORE: 84.8889

COIL: 0.7173

CONS_SCORE: 0.4085

DSS_SCORE: 0.2923

HELIX: 0.2207

FCONS_SCORE: 1.01

RIG_SCORE: 0.7962

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P394S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6752
p.P398H	TCGA-MP-A4TI	LUAD	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6583
p.P398H	DO45420	LUAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6583
p.P398L	TCGA-EE-A2GC	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6471
p.P398L	DO37839	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6471
p.V395G	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6421
p.V395G	DO50194	LGG	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6421
p.E392K	TCGA-AC-A23H	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	TCGA-E6-A2P9	UCEC	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	TCGA-EE-A29D	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO2401	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO38123	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO43714	UCEC	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392D	DO45281	LIRI	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5647
p.P398S	TCGA-D3-A8GI	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	DO50284	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	ACH-000917	Esophageal Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.E403K	TCGA-D8-A1JA	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.25
p.E403K	DO2819	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.25
p.H388Y	TCGA-D8-A141	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.H388Y	DO5514	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.S404C	ACH-001390	Breast Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.I405F	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.1944

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95069	Potassium channel subfamily K member 2	DEG_APCC_DBOX_1	392:400	ERDVLPPLL	APC,CDC20,FZR1	0.7946	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons