DegronMD

Uniprot ID: O95069

Source protein: Potassium channel subfamily K member 2

Source gene: KCNK2

Class: DEG_APCC_DBOX_1

Location: 392:400

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7946

ASA_SCORE: 84.8889

COIL: 0.7173

CONS_SCORE: 0.4085

DSS_SCORE: 0.2923

HELIX: 0.2207

FCONS_SCORE: 1.01

RIG_SCORE: 0.7962

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E392K	TCGA-AC-A23H	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	TCGA-E6-A2P9	UCEC	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	TCGA-EE-A29D	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO2401	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO38123	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.E392K	DO43714	UCEC	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.591
p.P398S	TCGA-D3-A8GI	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	DO50284	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	ACH-000917	Esophageal Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.P398S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5641
p.H388Y	TCGA-D8-A141	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.H388Y	DO5514	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.E403K	TCGA-D8-A1JA	BRCA	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.25
p.E403K	DO2819	BRCA	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.25
p.P398L	TCGA-EE-A2GC	SKCM	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6471
p.P398L	DO37839	SKCM	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6471
p.L407M	TCGA-KK-A8IH	PRAD	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.1389
p.L407M	DO219333	PRAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.1389
p.P398H	TCGA-MP-A4TI	LUAD	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6583
p.P398H	DO45420	LUAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6583
p.V395G	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.6421
p.V395G	DO50194	LGG	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6421
p.I405F	TCGA-S9-A6WD	LGG	TCGA	ERDVLPPLL	DEG_APCC_DBOX_1	0.1944
p.I405F	DO50194	LGG	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.1944
p.R382K	DO234213	ESAD	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.0556
p.E392D	DO45281	LIRI	ICGC	ERDVLPPLL	DEG_APCC_DBOX_1	0.5647
p.R382S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	ERDVLPPLL	DEG_APCC_DBOX_1	0.0556
p.R382S	ACH-000860	Lung Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	0.0556
p.R382S	NCI-H358	lung	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.0556
p.S404C	ACH-001390	Breast Cancer	CCLE	ERDVLPPLL	DEG_APCC_DBOX_1	0.2222
p.P394S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.6752
p.P383S	TE-4	oesophagus	COSMIC	ERDVLPPLL	DEG_APCC_DBOX_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERDVLPPLL

Degron related mutations and impact score

Drug responses associated with KCNK2 mutations

All proteins holding degron of ERDVLPPLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95069	Potassium channel subfamily K member 2	DEG_APCC_DBOX_1	392:400	ERDVLPPLL	APC,CDC20,FZR1	0.7946	More...