DegronMD - O95096(NKX2-2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A186S	TCGA-55-8092	LUAD	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1667
p.A186S	DO26220	LUAD	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1667
p.E193G	TCGA-AP-A0LS	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.6087
p.E193G	DO43178	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.6087
p.A204V	TCGA-AP-A1DK	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.A204V	DO42033	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R185C	TCGA-B5-A1MW	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1389
p.R185C	DO48372	BLCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1389
p.R185C	DO42913	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1389
p.M183I	TCGA-CQ-7064	HNSC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.0833
p.M183I	DO14162	HNSC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.0833
p.R187W	TCGA-D5-6540	COAD	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R187W	DO9708	COAD	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.M192I	TCGA-D9-A3Z3	SKCM	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.6507
p.M192I	DO37563	SKCM	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.6507
p.R187Q	TCGA-FW-A3R5	SKCM	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R187Q	DO37406	SKCM	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R187Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R187Q	ACH-000960	Leukemia	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.R187Q	REH	haematopoietic and lymphoid tissue	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1944
p.K190T	TCGA-HE-A5NF	KIRP	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2778
p.K190T	DO44515	KIRP	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2778
p.P196L	DO224957	BRCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.7582
p.V205M	DO233089	GACA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1667
p.V205M	DO233935	GACA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1667
p.T195K	DO228976	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.7306
p.A186D	DO228976	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.1667
p.P198T	DO228971	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.5919
p.G191V	DO219966	SARC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.3056
p.T195M	DO229253	THCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation altering degron motif	0.7423
p.A188T	SIDM00778	Colorectal Carcinoma	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2222
p.A188T	ACH-000403	Colon/Colorectal Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2222
p.A188T	NCI-H747	large intestine	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2222
p.G191D	SIDM00006	Other Solid Cancers	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.3056
p.G191D	ACH-001552	Skin Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.3056
p.G191D	MCC26	skin	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.3056
p.R201H	ACH-001518	Endometrial/Uterine Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	192:199	Mutation rewiring degron network	0.2778

Kaplan plot for NKX2-2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NKX2-2

UniProt ID: O95096

Entrez ID: 4821

Protein name: Homeobox protein Nkx-2.2 (Homeobox protein NK-2 homolog B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NKX2-2 in