DegronMD

Uniprot ID: O95096

Source protein: Homeobox protein Nkx-2.2

Source gene: NKX2-2

Class: DEG_SCF_FBW7_1

Location: 192:199

E3 ligase: FBXW7

DEGRON score: 0.7266

ASA_SCORE: 92.075

COIL: 0.9355

CONS_SCORE: 0.5983

DSS_SCORE: 0.471

HELIX: 0.0174

FCONS_SCORE: 0.7405

RIG_SCORE: 0.7037

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A186S	TCGA-55-8092	LUAD	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.1667
p.A186S	DO26220	LUAD	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1667
p.E193G	TCGA-AP-A0LS	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.6087
p.E193G	DO43178	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.6087
p.A204V	TCGA-AP-A1DK	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.A204V	DO42033	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R185C	TCGA-B5-A1MW	UCEC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.1389
p.R185C	DO48372	BLCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1389
p.R185C	DO42913	UCEC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1389
p.M183I	TCGA-CQ-7064	HNSC	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.0833
p.M183I	DO14162	HNSC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.0833
p.R187W	TCGA-D5-6540	COAD	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R187W	DO9708	COAD	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.M192I	TCGA-D9-A3Z3	SKCM	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.6507
p.M192I	DO37563	SKCM	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.6507
p.R187Q	TCGA-FW-A3R5	SKCM	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R187Q	DO37406	SKCM	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R187Q	SIDM00447	B-Lymphoblastic Leukemia	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R187Q	ACH-000960	Leukemia	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.R187Q	REH	haematopoietic_and_lymphoid_tissue	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	0.1944
p.K190T	TCGA-HE-A5NF	KIRP	TCGA	MEVTPLPS	DEG_SCF_FBW7_1	0.2778
p.K190T	DO44515	KIRP	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.2778
p.P196L	DO224957	BRCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.7582
p.V205M	DO233089	GACA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1667
p.V205M	DO233935	GACA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1667
p.T195K	DO228976	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.7306
p.A186D	DO228976	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.1667
p.P198T	DO228971	LICA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.5919
p.G191V	DO219966	SARC	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.3056
p.T195M	DO229253	THCA	ICGC	MEVTPLPS	DEG_SCF_FBW7_1	0.7423
p.A188T	SIDM00778	Colorectal Carcinoma	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	0.2222
p.A188T	ACH-000403	Colon/Colorectal Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	0.2222
p.A188T	NCI-H747	large_intestine	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	0.2222
p.G191D	SIDM00006	Other Solid Cancers	GDSC	MEVTPLPS	DEG_SCF_FBW7_1	0.3056
p.G191D	ACH-001552	Skin Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	0.3056
p.G191D	MCC26	skin	COSMIC	MEVTPLPS	DEG_SCF_FBW7_1	0.3056
p.R201H	ACH-001518	Endometrial/Uterine Cancer	CCLE	MEVTPLPS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEVTPLPS

Degron related mutations and impact score

Drug responses associated with NKX2-2 mutations

All proteins holding degron of MEVTPLPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95096	Homeobox protein Nkx-2.2	DEG_SCF_FBW7_1	192:199	MEVTPLPS	FBXW7	0.7266	More...