DegronMD - O95149(SNUPN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L38F	TCGA-A5-A0G1	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1944
p.L38F	DO42472	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1944
p.R46W	TCGA-AP-A0LM	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7523
p.R46W	DO43306	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7523
p.R55W	TCGA-AP-A0LP	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2222
p.R55W	DO43146	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2222
p.S53F	DO222621	BTCA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2778
p.S53F	SIDM01611	Endometrial Carcinoma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2778
p.R43H	DO233232	GACA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.7133
p.E49K	DO233229	GACA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.591
p.P33Q	DO228974	LICA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.0556
p.S53Y	DO229045	LICA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.2778
p.L38V	DO231541	LINC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation rewiring degron network	0.1944
p.R35I	DO43907	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation blocking phosphorylation signal	0.5556
p.R44H	SIDM00933	Breast Carcinoma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.8244
p.R44H	ACH-000856	Breast Cancer	CCLE	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.8244
p.R44H	CAL-51	breast	COSMIC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.8244
p.K34R	SIDM00567	Other Solid Cancers	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation blocking ubiquitination signal	0.5278
p.K34R	ACH-000776	Brain Cancer	CCLE	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation blocking ubiquitination signal	0.5278
p.K34R	ONS-76	central nervous system	COSMIC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation blocking ubiquitination signal	0.5278
p.R43C	SIDM00154	Mesothelioma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	43:51	Mutation altering degron motif	0.719

Kaplan plot for SNUPN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SNUPN

UniProt ID: O95149

Entrez ID: 10073

Protein name: Snurportin-1 (RNA U transporter 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SNUPN in