DegronMD

Uniprot ID: O95149

Source protein: Snurportin-1

Source gene: SNUPN

Class: DEG_APCC_DBOX_1

Location: 43:51

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9836

ASA_SCORE: 89.5222

COIL: 0.0402

CONS_SCORE: 0.6088

DSS_SCORE: 0.4181

HELIX: 0.9608

FCONS_SCORE: 1.2294

RIG_SCORE: 0.7742

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R44H	SIDM00933	Breast Carcinoma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	0.8244
p.R44H	ACH-000856	Breast Cancer	CCLE	RRRRLLELQ	DEG_APCC_DBOX_1	0.8244
p.R44H	CAL-51	breast	COSMIC	RRRRLLELQ	DEG_APCC_DBOX_1	0.8244
p.R46W	TCGA-AP-A0LM	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	0.7523
p.R46W	DO43306	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.7523
p.R43C	SIDM00154	Mesothelioma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	0.719
p.R43H	DO233232	GACA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.7133
p.E49K	DO233229	GACA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.591
p.R35I	DO43907	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.5556
p.K34R	SIDM00567	Other Solid Cancers	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	0.5278
p.K34R	ACH-000776	Brain Cancer	CCLE	RRRRLLELQ	DEG_APCC_DBOX_1	0.5278
p.K34R	ONS-76	central_nervous_system	COSMIC	RRRRLLELQ	DEG_APCC_DBOX_1	0.5278
p.S53F	DO222621	BTCA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.2778
p.S53F	SIDM01611	Endometrial Carcinoma	GDSC	RRRRLLELQ	DEG_APCC_DBOX_1	0.2778
p.S53Y	DO229045	LICA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.2778
p.R55W	TCGA-AP-A0LP	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	0.2222
p.R55W	DO43146	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.2222
p.L38F	TCGA-A5-A0G1	UCEC	TCGA	RRRRLLELQ	DEG_APCC_DBOX_1	0.1944
p.L38F	DO42472	UCEC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.1944
p.L38V	DO231541	LINC	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.1944
p.P33Q	DO228974	LICA	ICGC	RRRRLLELQ	DEG_APCC_DBOX_1	0.0556

Showing 1 to 21 of 21 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95149	Snurportin-1	DEG_APCC_DBOX_1	43:51	RRRRLLELQ	APC,CDC20,FZR1	0.9836	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons