DegronMD - O95170(FBXW10B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A245G	DO48372	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO48436	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO48407	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222741	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222752	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222785	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222782	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222788	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO222840	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO229016	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO229003	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO229505	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO51019	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO51001	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO228941	LICA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO228947	LICA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO52363	LUSC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO52391	LUSC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO218906	SKCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.A245G	DO218876	SKCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.M237I	DO6048	BRCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2778
p.M237I	ACH-000961	Endometrial/Uterine Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2778
p.G218R	DO222558	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0833
p.G218R	DO229211	THCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0833
p.F226L	DO233116	GACA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.T227P	DO233286	GACA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7031
p.S221Y	DO22237	LGG	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667
p.A219S	DO50825	LIRI	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1111
p.EE224EK	DO220879	MELA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0
p.A245S	DO29338	OV	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.0556
p.S235F	DO29668	OV	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.6871
p.E236K	DO36556	READ	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.E236K	DO37782	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.E236K	DO41524	UCEC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.E236K	SIDM00118	Colorectal Carcinoma	GDSC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.E236K	ACH-000948	Gastric Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.E236K	ACH-001081	Colon/Colorectal Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.3056
p.R232W	DO37951	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.7523
p.R228M	DO38033	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation altering degron motif	0.8632
p.S242Y	SIDM01611	Endometrial Carcinoma	GDSC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.5833
p.S242Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation blocking phosphorylation signal	0.5833
p.I223T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.2222
p.L243F	LS-411N	large intestine	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1111
p.H241D	NCI-H650	lung	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	227:235	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXW10B

UniProt ID: O95170

Entrez ID: 374286

Protein name: F-box and WD repeat domain containing protein 10B (CMT1A duplicated region transcript 1 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXW10B in