DegronMD

Uniprot ID: O95170

Source protein: F-box and WD repeat domain containing protein 10B

Source gene: FBXW10B

Class: DEG_APCC_DBOX_1

Location: 227:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5784

ASA_SCORE: 70.6667

COIL: 0.5501

CONS_SCORE: 0.2246

DSS_SCORE: 0.3397

HELIX: 0.3573

FCONS_SCORE: 1.0116

RIG_SCORE: 0.8045

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A245G	DO48372	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO48436	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO48407	BLCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222741	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222752	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222785	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222782	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222788	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO222840	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO229016	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO229003	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO229505	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO51019	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO51001	LAML	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO228941	LICA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO228947	LICA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO52363	LUSC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO52391	LUSC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO218906	SKCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.A245G	DO218876	SKCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.M237I	DO6048	BRCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.2778
p.M237I	ACH-000961	Endometrial/Uterine Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	0.2778
p.G218R	DO222558	COCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0833
p.G218R	DO229211	THCA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0833
p.F226L	DO233116	GACA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.T227P	DO233286	GACA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.7031
p.S221Y	DO22237	LGG	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.1667
p.A219S	DO50825	LIRI	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.1111
p.EE224EK	DO220879	MELA	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0
p.A245S	DO29338	OV	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.0556
p.S235F	DO29668	OV	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.6871
p.E236K	DO36556	READ	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.E236K	DO37782	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.E236K	DO41524	UCEC	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.E236K	SIDM00118	Colorectal Carcinoma	GDSC	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.E236K	ACH-000948	Gastric Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.E236K	ACH-001081	Colon/Colorectal Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	0.3056
p.R232W	DO37951	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.7523
p.R228M	DO38033	SKCM	ICGC	WRNSLRCIS	DEG_APCC_DBOX_1	0.8632
p.S242Y	SIDM01611	Endometrial Carcinoma	GDSC	WRNSLRCIS	DEG_APCC_DBOX_1	0.5833
p.S242Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	WRNSLRCIS	DEG_APCC_DBOX_1	0.5833
p.I223T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	0.2222
p.L243F	LS-411N	large_intestine	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	0.1111
p.H241D	NCI-H650	lung	COSMIC	WRNSLRCIS	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: WRNSLRCIS

Degron related mutations and impact score

Drug responses associated with FBXW10B mutations

All proteins holding degron of WRNSLRCIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95170	F-box and WD repeat domain containing protein 10B	DEG_APCC_DBOX_1	227:235	WRNSLRCIS	APC,CDC20,FZR1	0.5784	More...