DegronMD - O95185(UNC5C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P590T	TCGA-21-5787	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7031
p.P590T	TCGA-B3-4104	KIRP	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7031
p.P590T	DO26605	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7031
p.L588M	TCGA-85-A4JB	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.5999
p.L588M	DO45517	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.5999
p.L601F	TCGA-86-8075	LUAD	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1111
p.L601F	DO25386	LUAD	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1111
p.R603C	TCGA-BG-A220	UCEC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R603C	DO41784	UCEC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R603S	TCGA-BP-4972	KIRC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R603S	DO16194	KIRC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.S593I	TCGA-CD-5800	STAD	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7341
p.S593I	DO233282	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7341
p.S593I	DO38431	STAD	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7341
p.L587P	TCGA-K7-A5RG	LIHC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.6471
p.L587P	DO52304	LIHC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.6471
p.R603H	TCGA-O2-A52W	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R603H	DO229333	BTCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R603H	DO219225	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.R578K	TCGA-ZF-A9R7	BLCA	TCGA	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0833
p.R597K	DO219064	BLCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.2222
p.E585K	DO222798	COCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.2778
p.E585K	DO233093	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.2778
p.L587R	DO233840	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.8428
p.E594K	DO50649	KIRC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.3056
p.G581E	DO22295	LGG	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1667
p.G581E	DO37782	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1667
p.I578V	DO231944	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0833
p.H591Q	DO228986	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7582
p.P579Q	DO229019	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1111
p.H591Y	DO229050	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7229
p.T589N	DO229009	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7055
p.Y587F	DO231524	LINC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7528
p.R592W	DO45273	LIRI	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.8634
p.Q580H	DO27811	MALY	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.1389
p.K593N	DO35275	PACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.6918
p.R592M	DO37515	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.8632
p.R592M	DO47623	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.8632
p.R592K	DO37951	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7237
p.G595R	DO229229	THCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.2778
p.A577V	DO41331	UCEC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.0556
p.S593R	SIDM00333	Endometrial Carcinoma	GDSC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7427
p.S593R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7427
p.S593R	MFE-319	endometrium	COSMIC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation altering degron motif	0.7427
p.Q586R	BALL-1	haematopoietic and lymphoid tissue	COSMIC	LLTPVVS	DEG_SCF_FBW7_1	587:593	Mutation rewiring degron network	0.3056

Kaplan plot for UNC5C in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UNC5C

UniProt ID: O95185

Entrez ID: 8633

Protein name: Netrin receptor UNC5C (Protein unc-5 homolog 3) (Protein unc-5 homolog C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UNC5C in