DegronMD

Uniprot ID: O95185

Source protein: Netrin receptor UNC5C

Source gene: UNC5C

Class: DEG_SCF_FBW7_1

Location: 587:593

E3 ligase: FBXW7

DEGRON score: 0.7297

ASA_SCORE: 40.4

COIL: 0.3519

CONS_SCORE: 0.6287

DSS_SCORE: 0.4395

HELIX: 0.0269

FCONS_SCORE: 1.3675

RIG_SCORE: 0.7959

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P590T	TCGA-21-5787	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.7031
p.P590T	TCGA-B3-4104	KIRP	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.7031
p.P590T	DO26605	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7031
p.L588M	TCGA-85-A4JB	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.5999
p.L588M	DO45517	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.5999
p.L601F	TCGA-86-8075	LUAD	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.1111
p.L601F	DO25386	LUAD	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.1111
p.R603C	TCGA-BG-A220	UCEC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R603C	DO41784	UCEC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R603S	TCGA-BP-4972	KIRC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R603S	DO16194	KIRC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.S593I	TCGA-CD-5800	STAD	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.7341
p.S593I	DO233282	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7341
p.S593I	DO38431	STAD	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7341
p.L587P	TCGA-K7-A5RG	LIHC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.6471
p.L587P	DO52304	LIHC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.6471
p.R603H	TCGA-O2-A52W	LUSC	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R603H	DO229333	BTCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R603H	DO219225	LUSC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.R578K	TCGA-ZF-A9R7	BLCA	TCGA	LLTPVVS	DEG_SCF_FBW7_1	0.0833
p.R597K	DO219064	BLCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.2222
p.E585K	DO222798	COCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.2778
p.E585K	DO233093	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.2778
p.L587R	DO233840	GACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.8428
p.E594K	DO50649	KIRC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.3056
p.G581E	DO22295	LGG	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.1667
p.G581E	DO37782	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.1667
p.I578V	DO231944	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0833
p.H591Q	DO228986	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7582
p.P579Q	DO229019	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.1111
p.H591Y	DO229050	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7229
p.T589N	DO229009	LICA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7055
p.Y587F	DO231524	LINC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7528
p.R592W	DO45273	LIRI	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.8634
p.Q580H	DO27811	MALY	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.1389
p.K593N	DO35275	PACA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.6918
p.R592M	DO37515	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.8632
p.R592M	DO47623	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.8632
p.R592K	DO37951	SKCM	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.7237
p.G595R	DO229229	THCA	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.2778
p.A577V	DO41331	UCEC	ICGC	LLTPVVS	DEG_SCF_FBW7_1	0.0556
p.S593R	SIDM00333	Endometrial Carcinoma	GDSC	LLTPVVS	DEG_SCF_FBW7_1	0.7427
p.S593R	ACH-000988	Endometrial/Uterine Cancer	CCLE	LLTPVVS	DEG_SCF_FBW7_1	0.7427
p.S593R	MFE-319	endometrium	COSMIC	LLTPVVS	DEG_SCF_FBW7_1	0.7427
p.Q586R	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPVVS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LLTPVVS

Degron related mutations and impact score

Drug responses associated with UNC5C mutations

All proteins holding degron of LLTPVVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95185	Netrin receptor UNC5C	DEG_SCF_FBW7_1	587:593	LLTPVVS	FBXW7	0.7297	More...