DegronMD - O95299(NDUFA10)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D208Y	TCGA-86-7711	LUAD	TCGA	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7325
p.D208Y	DO25717	LUAD	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7325
p.R217Q	TCGA-A5-A0G2	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.R217Q	TCGA-DF-A2KU	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.R217Q	DO223286	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.R217Q	DO41235	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.0833
p.L203P	TCGA-AP-A059	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7582
p.L203P	DO41361	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7582
p.V210L	DO8730	COAD	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.P201T	DO222765	COCA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.A196E	DO229028	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.S206R	DO229026	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.7427
p.D197Y	DO50846	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.G200V	DO52205	LIHC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.S199N	DO231559	LINC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2222
p.T197N	DO49200	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.L203V	DO34544	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.5654
p.L201M	DO35242	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.2778
p.T197I	DO41235	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1667
p.V211I	SIDM00260	Gastric Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	SIDM00469	Pancreatic Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	SIDM01033	Bladder Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	SIDM00248	Gastric Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	KU-19-19	urinary tract	COSMIC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	MKN28	stomach	COSMIC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.V211I	PSN1	pancreas	COSMIC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.25
p.Y206H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation altering degron motif	0.6118
p.C196W	SIDM00044	Head and Neck Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389
p.C196W	PCI-30	upper aerodigestive tract	COSMIC	LVIYID	LIG_APCC_ABBA_1	203:208	Mutation rewiring degron network	0.1389

Kaplan plot for NDUFA10 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NDUFA10

UniProt ID: O95299

Entrez ID: 4705

Protein name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial (Complex I-42kD) (CI-42kD) (NADH-ubiquinone oxidoreductase 42 kDa subunit)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NDUFA10 in