DegronMD

Uniprot ID: O95299

Source protein: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

Source gene: NDUFA10

Class: LIG_APCC_ABBA_1

Location: 203:208

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5946

ASA_SCORE: 9.9833

COIL: 0.1455

CONS_SCORE: 0.7381

DSS_SCORE: 0.0982

HELIX: 0.0018

FCONS_SCORE: 1.4902

RIG_SCORE: 0.9282

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D208Y	TCGA-86-7711	LUAD	TCGA	LVIYID	LIG_APCC_ABBA_1	0.7325
p.D208Y	DO25717	LUAD	ICGC	LVIYID	LIG_APCC_ABBA_1	0.7325
p.R217Q	TCGA-A5-A0G2	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	0.0833
p.R217Q	TCGA-DF-A2KU	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	0.0833
p.R217Q	DO223286	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.0833
p.R217Q	DO41235	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.0833
p.L203P	TCGA-AP-A059	UCEC	TCGA	LVIYID	LIG_APCC_ABBA_1	0.7582
p.L203P	DO41361	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.7582
p.V210L	DO8730	COAD	ICGC	LVIYID	LIG_APCC_ABBA_1	0.2778
p.P201T	DO222765	COCA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.2778
p.A196E	DO229028	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.1389
p.S206R	DO229026	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.7427
p.D197Y	DO50846	LICA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.1667
p.G200V	DO52205	LIHC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.25
p.S199N	DO231559	LINC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.2222
p.T197N	DO49200	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.1667
p.L203V	DO34544	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.5654
p.L201M	DO35242	PACA	ICGC	LVIYID	LIG_APCC_ABBA_1	0.2778
p.T197I	DO41235	UCEC	ICGC	LVIYID	LIG_APCC_ABBA_1	0.1667
p.V211I	SIDM00260	Gastric Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	SIDM00469	Pancreatic Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	SIDM01033	Bladder Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	SIDM00248	Gastric Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	KU-19-19	urinary_tract	COSMIC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	MKN28	stomach	COSMIC	LVIYID	LIG_APCC_ABBA_1	0.25
p.V211I	PSN1	pancreas	COSMIC	LVIYID	LIG_APCC_ABBA_1	0.25
p.Y206H	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.6118
p.C196W	SIDM00044	Head and Neck Carcinoma	GDSC	LVIYID	LIG_APCC_ABBA_1	0.1389
p.C196W	PCI-30	upper_aerodigestive_tract	COSMIC	LVIYID	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LVIYID

Degron related mutations and impact score

Drug responses associated with NDUFA10 mutations

All proteins holding degron of LVIYID

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95299	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	LIG_APCC_ABBA_1	203:208	LVIYID	APC,CDC20,FZR1	0.5946	More...