DegronMD - O95390(GDF11)

GDF11

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P276L	TCGA-BL-A5ZZ	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1944
p.P276L	TCGA-C4-A0F6	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1944
p.P276L	DO44027	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1944
p.P276L	DO508	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1944
p.N292K	TCGA-GV-A3QI	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1667
p.N292K	DO470	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.1667
p.G277A	TCGA-PQ-A6FI	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.2222
p.G277A	DO48524	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.2222
p.E286V	SIDM02056	Pancreatic Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation altering degron motif	0.7693
p.M285T	SIDM00496	Thyroid Gland Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation altering degron motif	0.6312
p.M285T	ACH-001350	Thyroid Cancer	CCLE	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation altering degron motif	0.6312
p.M285T	HTC-C3	thyroid	COSMIC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation altering degron motif	0.6312
p.V271A	SIDM00238	Ovarian Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0556
p.V271A	ACH-000947	Ovarian Cancer	CCLE	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0556
p.V271A	OVK-18	ovary	COSMIC	LHPFME	LIG_APCC_ABBA_1	281:286	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc