DegronMD

Uniprot ID: O95390

Source protein: Growth/differentiation factor 11

Source gene: GDF11

Class: LIG_APCC_ABBA_1

Location: 281:286

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7816

ASA_SCORE: 69.3833

COIL: 0.5185

CONS_SCORE: 0.579

DSS_SCORE: 0.4167

HELIX: 0.0475

FCONS_SCORE: 1.2366

RIG_SCORE: 0.8049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P276L	TCGA-BL-A5ZZ	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	0.1944
p.P276L	TCGA-C4-A0F6	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	0.1944
p.P276L	DO44027	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	0.1944
p.P276L	DO508	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	0.1944
p.N292K	TCGA-GV-A3QI	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	0.1667
p.N292K	DO470	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	0.1667
p.G277A	TCGA-PQ-A6FI	BLCA	TCGA	LHPFME	LIG_APCC_ABBA_1	0.2222
p.G277A	DO48524	BLCA	ICGC	LHPFME	LIG_APCC_ABBA_1	0.2222
p.E286V	SIDM02056	Pancreatic Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	0.7693
p.M285T	SIDM00496	Thyroid Gland Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	0.6312
p.M285T	ACH-001350	Thyroid Cancer	CCLE	LHPFME	LIG_APCC_ABBA_1	0.6312
p.M285T	HTC-C3	thyroid	COSMIC	LHPFME	LIG_APCC_ABBA_1	0.6312
p.V271A	SIDM00238	Ovarian Carcinoma	GDSC	LHPFME	LIG_APCC_ABBA_1	0.0556
p.V271A	ACH-000947	Ovarian Cancer	CCLE	LHPFME	LIG_APCC_ABBA_1	0.0556
p.V271A	OVK-18	ovary	COSMIC	LHPFME	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95390	Growth/differentiation factor 11	LIG_APCC_ABBA_1	281:286	LHPFME	APC,CDC20,FZR1	0.7816	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons