DegronMD - O95436(SLC34A2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D86Y	TCGA-AA-3977	COAD	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.25
p.D86Y	TCGA-DF-A2KU	UCEC	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.25
p.D68G	TCGA-B6-A0WX	BRCA	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0833
p.G89E	TCGA-EE-A29D	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.G89E	TCGA-YD-A89C	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.S83A	TCGA-FI-A2D5	UCEC	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7588
p.D68N	TCGA-FW-A3R5	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0833
p.D67G	DO1537	BRCA	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556
p.F93L	DO8730	COAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556
p.F93L	DO47769	STAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556
p.D85Y	DO8730	COAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.D85Y	DO223286	UCEC	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.D67N	DO37406	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556
p.G88E	DO38123	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation substituting flanking lysine	0.3056
p.G88E	DO219501	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation substituting flanking lysine	0.3056
p.S82A	DO41331	UCEC	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7588
p.W70C	SIDM00428	Acute Myeloid Leukemia	GDSC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1389
p.W70C	ACH-000294	Leukemia	CCLE	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1389
p.W70C	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1389
p.S78L	SIDM00710	Small Cell Lung Carcinoma	GDSC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7667
p.S78L	ACH-000394	Lung Cancer	CCLE	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7667
p.S78L	NCI-H2081	lung	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7667
p.S77L	NCI-H2081	lung	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.7667
p.W69C	NB-4	haematopoietic and lymphoid tissue	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1111

Kaplan plot for SLC34A2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SLC34A2

UniProt ID: O95436

Entrez ID: 10568

Protein name: Sodium-dependent phosphate transport protein 2B (Sodium-phosphate transport protein 2B) (Na(+)-dependent phosphate cotransporter 2B) (NaPi3b) (Sodium/phosphate cotransporter 2B) (Na(+)/Pi cotransporter 2B) (NaPi-2b) (Solute carrier family 34 member 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SLC34A2 in