DegronMD

Uniprot ID: O95436

Source protein: Sodium-dependent phosphate transport protein 2B

Source gene: SLC34A2

Class: DEG_SCF_TRCP1_1

Location: 77:83

E3 ligase: BTRC

DEGRON score: 0.9197

ASA_SCORE: 77.0857

COIL: 0.7559

CONS_SCORE: 0.4059

DSS_SCORE: 0.3267

HELIX: 0.102

FCONS_SCORE: 1.0901

RIG_SCORE: 0.7974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D86Y	TCGA-AA-3977	COAD	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.25
p.D86Y	TCGA-DF-A2KU	UCEC	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.25
p.D68G	TCGA-B6-A0WX	BRCA	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.0833
p.G89E	TCGA-EE-A29D	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.1667
p.G89E	TCGA-YD-A89C	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.1667
p.S83A	TCGA-FI-A2D5	UCEC	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.7588
p.D68N	TCGA-FW-A3R5	SKCM	TCGA	DSGIKWS	DEG_SCF_TRCP1_1	0.0833
p.D67G	DO1537	BRCA	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.0556
p.F93L	DO8730	COAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.0556
p.F93L	DO47769	STAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.0556
p.D85Y	DO8730	COAD	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.2778
p.D85Y	DO223286	UCEC	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.2778
p.D67N	DO37406	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.0556
p.G88E	DO38123	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.3056
p.G88E	DO219501	SKCM	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.3056
p.S82A	DO41331	UCEC	ICGC	DSGIKWS	DEG_SCF_TRCP1_1	0.7588
p.W70C	SIDM00428	Acute Myeloid Leukemia	GDSC	DSGIKWS	DEG_SCF_TRCP1_1	0.1389
p.W70C	ACH-000294	Leukemia	CCLE	DSGIKWS	DEG_SCF_TRCP1_1	0.1389
p.W70C	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	0.1389
p.S78L	SIDM00710	Small Cell Lung Carcinoma	GDSC	DSGIKWS	DEG_SCF_TRCP1_1	0.7667
p.S78L	ACH-000394	Lung Cancer	CCLE	DSGIKWS	DEG_SCF_TRCP1_1	0.7667
p.S78L	NCI-H2081	lung	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	0.7667
p.S77L	NCI-H2081	lung	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	0.7667
p.W69C	NB-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIKWS	DEG_SCF_TRCP1_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95436	Sodium-dependent phosphate transport protein 2B	DEG_SCF_TRCP1_1	77:83	DSGIKWS	BTRC	0.9197	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons