DegronMD - O95447(LCA5L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S582F	TCGA-2W-A8YY	CESC	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation blocking phosphorylation signal	0.6389
p.S582F	DO223732	CESC	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation blocking phosphorylation signal	0.6389
p.R562T	TCGA-49-6743	LUAD	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.0833
p.R562T	DO26092	LUAD	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.0833
p.G573R	TCGA-EE-A29E	SKCM	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7568
p.G573R	DO37831	SKCM	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation altering degron motif	0.7568
p.E563K	TCGA-UF-A71B	HNSC	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1111
p.E563K	DO52107	HNSC	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.1111
p.G579D	ACH-001060	Lymphoma	CCLE	DSGYEPS	DEG_SCF_TRCP1_1	571:577	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons