DegronMD

Uniprot ID: O95447

Source protein: Lebercilin-like protein

Source gene: LCA5L

Class: DEG_SCF_TRCP1_1

Location: 571:577

E3 ligase: BTRC

DEGRON score: 0.9824

ASA_SCORE: 45.5

COIL: 0.7547

CONS_SCORE: 0.4661

DSS_SCORE: 0.5258

HELIX: 0.1051

FCONS_SCORE: 1.2665

RIG_SCORE: 0.6173

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S582F	TCGA-2W-A8YY	CESC	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	0.6389
p.S582F	DO223732	CESC	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	0.6389
p.R562T	TCGA-49-6743	LUAD	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	0.0833
p.R562T	DO26092	LUAD	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	0.0833
p.G573R	TCGA-EE-A29E	SKCM	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	0.7568
p.G573R	DO37831	SKCM	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	0.7568
p.E563K	TCGA-UF-A71B	HNSC	TCGA	DSGYEPS	DEG_SCF_TRCP1_1	0.1111
p.E563K	DO52107	HNSC	ICGC	DSGYEPS	DEG_SCF_TRCP1_1	0.1111
p.G579D	ACH-001060	Lymphoma	CCLE	DSGYEPS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95447	Lebercilin-like protein	DEG_SCF_TRCP1_1	571:577	DSGYEPS	BTRC	0.9824	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons