DegronMD - O95450(ADAMTS2)

ADAMTS2

UniProt ID: O95450

Entrez ID: 9509

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y834F	TCGA-05-4390	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.6417
p.Y834F	DO23562	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.6417
p.S829L	TCGA-05-4395	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.2222
p.S829L	DO25444	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.2222
p.N847K	TCGA-21-1079	LUSC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1111
p.N847K	TCGA-DK-A3IU	BLCA	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1111
p.N847K	DO612	BLCA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1111
p.N847K	DO26846	LUSC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1111
p.H837N	TCGA-44-A47F	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7423
p.H837N	DO24180	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7423
p.N846K	TCGA-55-A492	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1389
p.N846K	DO23708	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1389
p.V848I	TCGA-A5-A0G2	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.V848I	TCGA-LN-A8I1	ESCA	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.V848I	DO41235	UCEC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.D844N	TCGA-A5-A2K5	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D844N	DO220903	MELA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D844N	DO41379	UCEC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D844N	SIDM00083	Glioblastoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D844N	ACH-000273	Brain Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D844N	SF539	central nervous system	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.D845N	TCGA-AX-A05Z	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.D845N	TCGA-B5-A0JY	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.D845N	DO233737	GACA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.D845N	DO40884	UCEC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.D845N	DO43041	UCEC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.G824R	TCGA-EE-A2GB	SKCM	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	TCGA-EE-A2MM	SKCM	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	TCGA-FS-A1Z0	SKCM	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	DO222678	MELA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	DO222683	MELA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	DO37770	SKCM	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	DO37417	SKCM	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824R	DO37431	SKCM	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824V	TCGA-G9-6367	PRAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.G824V	DO36234	PRAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.M835I	TCGA-WE-A8ZQ	SKCM	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.6507
p.M835I	DO51288	SKCM	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.6507
p.R827Q	DO227646	COCA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.D844H	DO228377	LICA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1944
p.R827W	DO51527	PACA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667
p.T831M	DO46889	RECA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.2778
p.G824A	DO218878	SKCA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.0833
p.N846S	SIDM00567	Other Solid Cancers	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1389
p.N846S	ACH-000776	Brain Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1389
p.N846S	ONS-76	central nervous system	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1389
p.I836F	SIDM00537	Colorectal Carcinoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7415
p.I836F	ACH-000982	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7415
p.I836F	ACH-001345	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7415
p.I836F	GP5d	large intestine	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation altering degron motif	0.7415
p.Y832C	SIDM00217	Colorectal Carcinoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.3056
p.Y832C	ACH-000999	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.3056
p.Y832C	SNU-1040	large intestine	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.3056
p.V843F	ACH-001529	Endometrial/Uterine Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.2222
p.D845H	ACH-001677	Lymphoma	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	833:839	Mutation rewiring degron network	0.1667

Kaplan plot for ADAMTS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc