DegronMD

Uniprot ID: O95450

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 2

Source gene: ADAMTS2

Class: LIG_APCC_ABBAyCdc20_2

Location: 833:839

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6637

ASA_SCORE: 54.5714

COIL: 0.3003

CONS_SCORE: 0.5419

DSS_SCORE: 0.1303

HELIX: 0.0829

FCONS_SCORE: 1.2366

RIG_SCORE: 0.9031

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H837N	TCGA-44-A47F	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7423
p.H837N	DO24180	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7423
p.I836F	SIDM00537	Colorectal Carcinoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7415
p.I836F	ACH-000982	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7415
p.I836F	ACH-001345	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7415
p.I836F	GP5d	large_intestine	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.7415
p.M835I	TCGA-WE-A8ZQ	SKCM	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.6507
p.M835I	DO51288	SKCM	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.6507
p.Y834F	TCGA-05-4390	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.6417
p.Y834F	DO23562	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.6417
p.Y832C	SIDM00217	Colorectal Carcinoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y832C	ACH-000999	Colon/Colorectal Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y832C	SNU-1040	large_intestine	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.3056
p.T831M	DO46889	RECA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.2778
p.S829L	TCGA-05-4395	LUAD	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.2222
p.S829L	DO25444	LUAD	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.2222
p.V843F	ACH-001529	Endometrial/Uterine Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.2222
p.D844N	TCGA-A5-A2K5	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844N	DO220903	MELA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844N	DO41379	UCEC	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844N	SIDM00083	Glioblastoma	GDSC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844N	ACH-000273	Brain Cancer	CCLE	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844N	SF539	central_nervous_system	COSMIC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D844H	DO228377	LICA	ICGC	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1944
p.D845N	TCGA-AX-A05Z	UCEC	TCGA	KYMIHED	LIG_APCC_ABBAyCdc20_2	0.1667

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Drug responses associated with ADAMTS2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of KYMIHED

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95450	A disintegrin and metalloproteinase with thrombospondin motifs 2	LIG_APCC_ABBAyCdc20_2	833:839	KYMIHED	APC,CDC20,FZR1	0.6637	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KYMIHED

Degron related mutations and impact score

Drug responses associated with ADAMTS2 mutations

All proteins holding degron of KYMIHED