DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
KYMIHED
Uniprot ID:
O95450
Source protein:
A disintegrin and metalloproteinase with thrombospondin motifs 2
Source gene:
ADAMTS2
Class:
LIG_APCC_ABBAyCdc20_2
Location:
833:839
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6637
ASA_SCORE:
54.5714
COIL:
0.3003
CONS_SCORE:
0.5419
DSS_SCORE:
0.1303
HELIX:
0.0829
FCONS_SCORE:
1.2366
RIG_SCORE:
0.9031
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Y834F
TCGA-05-4390
LUAD
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.6417
p.Y834F
DO23562
LUAD
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.6417
p.S829L
TCGA-05-4395
LUAD
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.2222
p.S829L
DO25444
LUAD
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.2222
p.N847K
TCGA-21-1079
LUSC
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1111
p.N847K
TCGA-DK-A3IU
BLCA
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1111
p.N847K
DO612
BLCA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1111
p.N847K
DO26846
LUSC
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1111
p.H837N
TCGA-44-A47F
LUAD
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7423
p.H837N
DO24180
LUAD
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7423
p.N846K
TCGA-55-A492
LUAD
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1389
p.N846K
DO23708
LUAD
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1389
p.V848I
TCGA-A5-A0G2
UCEC
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.V848I
TCGA-LN-A8I1
ESCA
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.V848I
DO41235
UCEC
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.D844N
TCGA-A5-A2K5
UCEC
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D844N
DO220903
MELA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D844N
DO41379
UCEC
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D844N
SIDM00083
Glioblastoma
GDSC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D844N
ACH-000273
Brain Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D844N
SF539
central_nervous_system
COSMIC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.D845N
TCGA-AX-A05Z
UCEC
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.D845N
TCGA-B5-A0JY
UCEC
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.D845N
DO233737
GACA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.D845N
DO40884
UCEC
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.D845N
DO43041
UCEC
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.G824R
TCGA-EE-A2GB
SKCM
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
TCGA-EE-A2MM
SKCM
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
TCGA-FS-A1Z0
SKCM
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
DO222678
MELA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
DO222683
MELA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
DO37770
SKCM
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
DO37417
SKCM
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824R
DO37431
SKCM
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824V
TCGA-G9-6367
PRAD
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.G824V
DO36234
PRAD
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.M835I
TCGA-WE-A8ZQ
SKCM
TCGA
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.6507
p.M835I
DO51288
SKCM
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.6507
p.R827Q
DO227646
COCA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.D844H
DO228377
LICA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1944
p.R827W
DO51527
PACA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
p.T831M
DO46889
RECA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.2778
p.G824A
DO218878
SKCA
ICGC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.0833
p.N846S
SIDM00567
Other Solid Cancers
GDSC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1389
p.N846S
ACH-000776
Brain Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1389
p.N846S
ONS-76
central_nervous_system
COSMIC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1389
p.I836F
SIDM00537
Colorectal Carcinoma
GDSC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7415
p.I836F
ACH-000982
Colon/Colorectal Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7415
p.I836F
ACH-001345
Colon/Colorectal Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7415
p.I836F
GP5d
large_intestine
COSMIC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.7415
p.Y832C
SIDM00217
Colorectal Carcinoma
GDSC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.3056
p.Y832C
ACH-000999
Colon/Colorectal Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.3056
p.Y832C
SNU-1040
large_intestine
COSMIC
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.3056
p.V843F
ACH-001529
Endometrial/Uterine Cancer
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.2222
p.D845H
ACH-001677
Lymphoma
CCLE
KYMIHED
LIG_APCC_ABBAyCdc20_2
0.1667
Drug responses associated with ADAMTS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KYMIHED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95450
A disintegrin and metalloproteinase with thrombospondin motifs 2
LIG_APCC_ABBAyCdc20_2
833:839
KYMIHED
APC,CDC20,FZR1
0.6637
More...