DegronMD - O95502(NPTXR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V309M	TCGA-A5-A0G1	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.V309M	TCGA-AG-3902	READ	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.V309M	DO234230	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.V309M	DO233888	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.V309M	DO36407	READ	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.V309M	DO42472	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6097
p.A312T	TCGA-AB-2938	LAML	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6028
p.A312T	DO21085	LAML	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6028
p.R310Q	TCGA-BR-7703	STAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	DO38232	STAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.A321T	TCGA-BR-8078	STAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.A321T	DO234453	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.A321T	DO38288	STAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.N303S	TCGA-D1-A15X	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.N303S	DO43274	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.A307D	TCGA-DD-A4NS	LIHC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2778
p.A307D	DO45017	LIHC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2778
p.R310W	TCGA-EY-A1G8	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.8634
p.R310W	DO233272	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.8634
p.R310W	DO43578	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.8634
p.M305I	TCGA-XK-AAIW	PRAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.M305I	DO234408	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.M305I	DO51407	PRAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.R326W	DO233259	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0833
p.T320A	DO229234	THCA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.25
p.M323T	SIDM00425	Ovarian Carcinoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.M323T	ACH-000663	Ovarian Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1667
p.R308C	SIDM01088	Endometrial Carcinoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.R308C	ACH-000965	Endometrial/Uterine Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.R308C	RL95-2	endometrium	COSMIC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S327F	SIDM00003	Melanoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.S327F	ACH-000884	Skin Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.S327F	ACH-002159	Skin Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.S327F	M14	skin	COSMIC	VRKALPELY	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPTXR

UniProt ID: O95502

Entrez ID: 23467

Protein name: Neuronal pentraxin receptor

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPTXR in