DegronMD

Uniprot ID: O95502

Source protein: Neuronal pentraxin receptor

Source gene: NPTXR

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7603

ASA_SCORE: 73.1333

COIL: 0.7663

CONS_SCORE: 0.6683

DSS_SCORE: 0.0407

HELIX: 0.0194

FCONS_SCORE: 0.9424

RIG_SCORE: 0.909

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V309M	TCGA-A5-A0G1	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.V309M	TCGA-AG-3902	READ	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.V309M	DO234230	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.V309M	DO233888	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.V309M	DO36407	READ	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.V309M	DO42472	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.6097
p.A312T	TCGA-AB-2938	LAML	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.6028
p.A312T	DO21085	LAML	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.6028
p.R310Q	TCGA-BR-7703	STAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.7329
p.R310Q	DO38232	STAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.7329
p.A321T	TCGA-BR-8078	STAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.A321T	DO234453	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.A321T	DO38288	STAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.N303S	TCGA-D1-A15X	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.1667
p.N303S	DO43274	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.1667
p.A307D	TCGA-DD-A4NS	LIHC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.2778
p.A307D	DO45017	LIHC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.2778
p.R310W	TCGA-EY-A1G8	UCEC	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.8634
p.R310W	DO233272	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.8634
p.R310W	DO43578	UCEC	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.8634
p.M305I	TCGA-XK-AAIW	PRAD	TCGA	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.M305I	DO234408	ESAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.M305I	DO51407	PRAD	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.2222
p.R326W	DO233259	GACA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.0833
p.T320A	DO229234	THCA	ICGC	VRKALPELY	DEG_APCC_DBOX_1	0.25
p.M323T	SIDM00425	Ovarian Carcinoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	0.1667
p.M323T	ACH-000663	Ovarian Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	0.1667
p.R308C	SIDM01088	Endometrial Carcinoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	0.3056
p.R308C	ACH-000965	Endometrial/Uterine Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	0.3056
p.R308C	RL95-2	endometrium	COSMIC	VRKALPELY	DEG_APCC_DBOX_1	0.3056
p.S327F	SIDM00003	Melanoma	GDSC	VRKALPELY	DEG_APCC_DBOX_1	0.0556
p.S327F	ACH-000884	Skin Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	0.0556
p.S327F	ACH-002159	Skin Cancer	CCLE	VRKALPELY	DEG_APCC_DBOX_1	0.0556
p.S327F	M14	skin	COSMIC	VRKALPELY	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRKALPELY

Degron related mutations and impact score

Drug responses associated with NPTXR mutations

All proteins holding degron of VRKALPELY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95502	Neuronal pentraxin receptor	DEG_APCC_DBOX_1	309:317	VRKALPELY	APC,CDC20,FZR1	0.7603	More...