DegronMD - O95620(DUS4L)

DUS4L

UniProt ID: O95620

Entrez ID: 11062

Protein name: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (EC 1.3.1.90) (pp35) (tRNA-dihydrouridine synthase 4-like)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G152A	TCGA-AG-3894	READ	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1667
p.G152A	DO36419	READ	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1667
p.K174N	TCGA-AP-A0LG	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation substituting flanking lysine	0.1667
p.K174N	DO41823	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation substituting flanking lysine	0.1667
p.L171I	TCGA-B5-A1MR	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1389
p.L171I	TCGA-EO-A3B0	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1389
p.L171I	DO219773	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1389
p.L171I	DO41758	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1389
p.T150A	TCGA-BS-A0UF	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1111
p.T150A	DO41488	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1111
p.F153C	TCGA-F5-6814	READ	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1944
p.F153C	DO36556	READ	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1944
p.K166T	TCGA-IR-A3LH	CESC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.2778
p.K166T	DO44381	CESC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.2778
p.K158T	TCGA-VQ-AA6D	STAD	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation altering degron motif	0.7306
p.K158T	DO222392	STAD	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation altering degron motif	0.7306
p.S156Y	DO222884	COCA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.2778
p.D170Y	DO229027	LICA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1667
p.F153Y	DO232761	PBCA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	158:164	Mutation rewiring degron network	0.1944

Kaplan plot for DUS4L in

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*NOTE: the Kaplan plots were collected from OncoLnc