DegronMD

Uniprot ID: O95620

Source protein: tRNA-dihydrouridine

Source gene: DUS4L

Class: LIG_APCC_ABBAyCdc20_2

Location: 158:164

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8394

ASA_SCORE: 51.1857

COIL: 0.5519

CONS_SCORE: 0.559

DSS_SCORE: 0.1675

HELIX: 0.0243

FCONS_SCORE: 1.2718

RIG_SCORE: 0.8803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G152A	TCGA-AG-3894	READ	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.G152A	DO36419	READ	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K174N	TCGA-AP-A0LG	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K174N	DO41823	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L171I	TCGA-B5-A1MR	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L171I	TCGA-EO-A3B0	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L171I	DO219773	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.L171I	DO41758	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T150A	TCGA-BS-A0UF	UCEC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T150A	DO41488	UCEC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1111
p.F153C	TCGA-F5-6814	READ	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.F153C	DO36556	READ	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1944
p.K166T	TCGA-IR-A3LH	CESC	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K166T	DO44381	CESC	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K158T	TCGA-VQ-AA6D	STAD	TCGA	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.7306
p.K158T	DO222392	STAD	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.7306
p.S156Y	DO222884	COCA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D170Y	DO229027	LICA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1667
p.F153Y	DO232761	PBCA	ICGC	KIRIHDD	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95620	tRNA-dihydrouridine	LIG_APCC_ABBAyCdc20_2	158:164	KIRIHDD	APC,CDC20,FZR1	0.8394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons