DegronMD - O95807(TMEM50A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I23V	TCGA-77-8148	LUSC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.0833
p.I23V	DO26458	LUSC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.0833
p.A42T	TCGA-CM-4743	COAD	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.2778
p.A42T	DO8103	COAD	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.2778
p.A28T	TCGA-EY-A5W2	UCEC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.2222
p.A28T	DO48177	UCEC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.2222
p.T48P	TCGA-FU-A3HZ	CESC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.1111
p.T48P	DO6308	CESC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.1111
p.A24S	DO229025	LICA	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation rewiring degron network	0.1111
p.F32L	SIDM00193	Colorectal Carcinoma	GDSC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation altering degron motif	0.6981
p.F32L	ACH-000991	Colon/Colorectal Cancer	CCLE	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation altering degron motif	0.6981
p.F32L	SNU-81	large intestine	COSMIC	FFTGWWIII	DEG_MDM2_SWIB_1	32:40	Mutation altering degron motif	0.6981

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons