DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
FFTGWWIII
Uniprot ID:
O95807
Source protein:
Transmembrane protein 50A
Source gene:
TMEM50A
Class:
DEG_MDM2_SWIB_1
Location:
32:40
E3 ligase:
MDM2
DEGRON score:
0.5788
ASA_SCORE:
21.9
COIL:
0.1196
CONS_SCORE:
0.7378
DSS_SCORE:
0.0011
HELIX:
0.8152
FCONS_SCORE:
1.4197
RIG_SCORE:
1.0761
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F32L
SIDM00193
Colorectal Carcinoma
GDSC
FFTGWWIII
DEG_MDM2_SWIB_1
0.6981
p.F32L
ACH-000991
Colon/Colorectal Cancer
CCLE
FFTGWWIII
DEG_MDM2_SWIB_1
0.6981
p.F32L
SNU-81
large_intestine
COSMIC
FFTGWWIII
DEG_MDM2_SWIB_1
0.6981
p.A42T
TCGA-CM-4743
COAD
TCGA
FFTGWWIII
DEG_MDM2_SWIB_1
0.2778
p.A42T
DO8103
COAD
ICGC
FFTGWWIII
DEG_MDM2_SWIB_1
0.2778
p.A28T
TCGA-EY-A5W2
UCEC
TCGA
FFTGWWIII
DEG_MDM2_SWIB_1
0.2222
p.A28T
DO48177
UCEC
ICGC
FFTGWWIII
DEG_MDM2_SWIB_1
0.2222
p.T48P
TCGA-FU-A3HZ
CESC
TCGA
FFTGWWIII
DEG_MDM2_SWIB_1
0.1111
p.T48P
DO6308
CESC
ICGC
FFTGWWIII
DEG_MDM2_SWIB_1
0.1111
p.A24S
DO229025
LICA
ICGC
FFTGWWIII
DEG_MDM2_SWIB_1
0.1111
p.I23V
TCGA-77-8148
LUSC
TCGA
FFTGWWIII
DEG_MDM2_SWIB_1
0.0833
p.I23V
DO26458
LUSC
ICGC
FFTGWWIII
DEG_MDM2_SWIB_1
0.0833
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Drug responses associated with TMEM50A mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of FFTGWWIII
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95807
Transmembrane protein 50A
DEG_MDM2_SWIB_1
32:40
FFTGWWIII
MDM2
0.5788
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