DegronMD

Uniprot ID: O95807

Source protein: Transmembrane protein 50A

Source gene: TMEM50A

Class: DEG_MDM2_SWIB_1

Location: 32:40

E3 ligase: MDM2

DEGRON score: 0.5788

ASA_SCORE: 21.9

COIL: 0.1196

CONS_SCORE: 0.7378

DSS_SCORE: 0.0011

HELIX: 0.8152

FCONS_SCORE: 1.4197

RIG_SCORE: 1.0761

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I23V	TCGA-77-8148	LUSC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	0.0833
p.I23V	DO26458	LUSC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	0.0833
p.A42T	TCGA-CM-4743	COAD	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	0.2778
p.A42T	DO8103	COAD	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	0.2778
p.A28T	TCGA-EY-A5W2	UCEC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	0.2222
p.A28T	DO48177	UCEC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	0.2222
p.T48P	TCGA-FU-A3HZ	CESC	TCGA	FFTGWWIII	DEG_MDM2_SWIB_1	0.1111
p.T48P	DO6308	CESC	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	0.1111
p.A24S	DO229025	LICA	ICGC	FFTGWWIII	DEG_MDM2_SWIB_1	0.1111
p.F32L	SIDM00193	Colorectal Carcinoma	GDSC	FFTGWWIII	DEG_MDM2_SWIB_1	0.6981
p.F32L	ACH-000991	Colon/Colorectal Cancer	CCLE	FFTGWWIII	DEG_MDM2_SWIB_1	0.6981
p.F32L	SNU-81	large_intestine	COSMIC	FFTGWWIII	DEG_MDM2_SWIB_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95807	Transmembrane protein 50A	DEG_MDM2_SWIB_1	32:40	FFTGWWIII	MDM2	0.5788	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons