DegronMD - O95864(FADS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E15K	TCGA-FD-A3B6	BLCA	TCGA	EREVSVPTF	DEG_COP1_1	13:21	Mutation altering degron motif	0.7022
p.E15K	DO458	BLCA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation altering degron motif	0.7022
p.H17R	DO222864	COCA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation altering degron motif	0.8244
p.E15A	DO233081	GACA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation altering degron motif	0.7701
p.A29S	DO233280	GACA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.1111
p.G8S	DO11854	GBM	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation blocking ubiquitination signal	0.6389
p.S22I	DO228948	LICA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.3056
p.V12L	DO228971	LICA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.3056
p.Q23H	DO232224	PBCA	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.2778
p.T24N	DO51407	PRAD	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.25
p.P6S	DO220260	SARC	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.1389
p.C8R	DO219464	SKCM	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation blocking ubiquitination signal	0.6389
p.P6H	DO47819	STAD	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.1389
p.F9C	DO43907	UCEC	ICGC	EREVSVPTF	DEG_COP1_1	13:21	Mutation rewiring degron network	0.2222
p.G3V	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	EREVSVPTF	DEG_COP1_1	13:21	Mutation substituting flanking lysine	0.1667
p.G3V	ACH-000769	Lung Cancer	CCLE	EREVSVPTF	DEG_COP1_1	13:21	Mutation substituting flanking lysine	0.1667
p.G3V	LK-2	lung	COSMIC	EREVSVPTF	DEG_COP1_1	13:21	Mutation substituting flanking lysine	0.1667

Kaplan plot for FADS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FADS2

UniProt ID: O95864

Entrez ID: 9415

Protein name: Acyl-CoA 6-desaturase (EC 1.14.19.3) (Delta(6) fatty acid desaturase) (D6D) (Delta(6) desaturase) (Delta-6 desaturase) (Fatty acid desaturase 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FADS2 in