DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
EREVSVPTF
Uniprot ID:
O95864
Source protein:
Acyl-CoA 6-desaturase
Source gene:
FADS2
Class:
DEG_COP1_1
Location:
13:21
E3 ligase:
COP1
DEGRON score:
0.9554
ASA_SCORE:
83.4111
COIL:
0.8303
CONS_SCORE:
0.2657
DSS_SCORE:
0.4578
HELIX:
0.1087
FCONS_SCORE:
0.8485
RIG_SCORE:
0.7653
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E15K
TCGA-FD-A3B6
BLCA
TCGA
EREVSVPTF
DEG_COP1_1
0.7022
p.E15K
DO458
BLCA
ICGC
EREVSVPTF
DEG_COP1_1
0.7022
p.H17R
DO222864
COCA
ICGC
EREVSVPTF
DEG_COP1_1
0.8244
p.E15A
DO233081
GACA
ICGC
EREVSVPTF
DEG_COP1_1
0.7701
p.A29S
DO233280
GACA
ICGC
EREVSVPTF
DEG_COP1_1
0.1111
p.G8S
DO11854
GBM
ICGC
EREVSVPTF
DEG_COP1_1
0.6389
p.S22I
DO228948
LICA
ICGC
EREVSVPTF
DEG_COP1_1
0.3056
p.V12L
DO228971
LICA
ICGC
EREVSVPTF
DEG_COP1_1
0.3056
p.Q23H
DO232224
PBCA
ICGC
EREVSVPTF
DEG_COP1_1
0.2778
p.T24N
DO51407
PRAD
ICGC
EREVSVPTF
DEG_COP1_1
0.25
p.P6S
DO220260
SARC
ICGC
EREVSVPTF
DEG_COP1_1
0.1389
p.C8R
DO219464
SKCM
ICGC
EREVSVPTF
DEG_COP1_1
0.6389
p.P6H
DO47819
STAD
ICGC
EREVSVPTF
DEG_COP1_1
0.1389
p.F9C
DO43907
UCEC
ICGC
EREVSVPTF
DEG_COP1_1
0.2222
p.G3V
SIDM00548
Squamous Cell Lung Carcinoma
GDSC
EREVSVPTF
DEG_COP1_1
0.1667
p.G3V
ACH-000769
Lung Cancer
CCLE
EREVSVPTF
DEG_COP1_1
0.1667
p.G3V
LK-2
lung
COSMIC
EREVSVPTF
DEG_COP1_1
0.1667
Drug responses associated with FADS2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EREVSVPTF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O95864
Acyl-CoA 6-desaturase
DEG_COP1_1
13:21
EREVSVPTF
COP1
0.9554
More...