DegronMD - O95900(TRUB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R51C	TCGA-22-4594	LUSC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.8301
p.R51C	DO222884	COCA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.8301
p.R51C	DO27476	LUSC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.8301
p.A45T	TCGA-AG-A02N	READ	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.1944
p.A45T	DO37146	READ	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.1944
p.K42R	TCGA-CZ-4863	KIRC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation substituting flanking lysine	0.2222
p.K42R	DO18691	KIRC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation substituting flanking lysine	0.2222
p.R51H	TCGA-EO-A3B0	UCEC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.8244
p.R51H	DO219773	UCEC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.8244
p.R49H	TCGA-IB-7651	PAAD	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.R49H	DO46657	PAAD	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.P43L	DO228335	EOPC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.1389
p.P56S	DO234271	ESAD	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.5641
p.L54M	DO229037	LICA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation altering degron motif	0.711
p.P46H	DO229045	LICA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2222
p.P43T	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.1389
p.P43T	SIDM01128	Small Cell Lung Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.1389
p.R49C	SIDM01617	Endometrial Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.R49C	ACH-000994	Endometrial/Uterine Cancer	CCLE	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.3056
p.S60G	ACH-001607	Gallbladder Cancer	CCLE	VRFLLGPME	DEG_APCC_DBOX_1	50:58	Mutation rewiring degron network	0.2778

Kaplan plot for TRUB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TRUB2

UniProt ID: O95900

Entrez ID: 26995

Protein name: Pseudouridylate synthase TRUB2, mitochondrial (EC 5.4.99.-) (TruB pseudouridine synthase homolog 2) (tRNA pseudouridine 55 synthase TRUB2) (Psi55 synthase TRUB2) (EC 5.4.99.25)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TRUB2 in