DegronMD

Uniprot ID: O95900

Source protein: Pseudouridylate synthase TRUB2, mitochondrial

Source gene: TRUB2

Class: DEG_APCC_DBOX_1

Location: 50:58

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.981

ASA_SCORE: 77.6222

COIL: 0.6922

CONS_SCORE: 0.2571

DSS_SCORE: 0.5172

HELIX: 0.0382

FCONS_SCORE: 0.9222

RIG_SCORE: 0.7435

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R51C	TCGA-22-4594	LUSC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	0.8301
p.R51C	DO222884	COCA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.8301
p.R51C	DO27476	LUSC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.8301
p.A45T	TCGA-AG-A02N	READ	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	0.1944
p.A45T	DO37146	READ	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.1944
p.K42R	TCGA-CZ-4863	KIRC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	0.2222
p.K42R	DO18691	KIRC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.2222
p.R51H	TCGA-EO-A3B0	UCEC	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	0.8244
p.R51H	DO219773	UCEC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.8244
p.R49H	TCGA-IB-7651	PAAD	TCGA	VRFLLGPME	DEG_APCC_DBOX_1	0.3056
p.R49H	DO46657	PAAD	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.3056
p.P43L	DO228335	EOPC	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.1389
p.P56S	DO234271	ESAD	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.5641
p.L54M	DO229037	LICA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.711
p.P46H	DO229045	LICA	ICGC	VRFLLGPME	DEG_APCC_DBOX_1	0.2222
p.P43T	SIDM00724	Non-Small Cell Lung Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	0.1389
p.P43T	SIDM01128	Small Cell Lung Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	0.1389
p.R49C	SIDM01617	Endometrial Carcinoma	GDSC	VRFLLGPME	DEG_APCC_DBOX_1	0.3056
p.R49C	ACH-000994	Endometrial/Uterine Cancer	CCLE	VRFLLGPME	DEG_APCC_DBOX_1	0.3056
p.S60G	ACH-001607	Gallbladder Cancer	CCLE	VRFLLGPME	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95900	Pseudouridylate synthase TRUB2, mitochondrial	DEG_APCC_DBOX_1	50:58	VRFLLGPME	APC,CDC20,FZR1	0.981	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons