DegronMD - O95936(EOMES)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S630F	TCGA-A5-A0G1	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.2778
p.L645M	TCGA-AP-A051	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.1389
p.S627Y	TCGA-E6-A1LX	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation blocking phosphorylation signal	0.6389
p.S630P	TCGA-EO-A22X	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.2778
p.S627F	TCGA-EY-A1G8	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation blocking phosphorylation signal	0.6389
p.E631G	SIDM01045	Endometrial Carcinoma	GDSC	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.3056
p.E631G	EN	endometrium	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.3056
p.R644W	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.1667
p.R644W	HT-115	large intestine	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.1667
p.A639D	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.3056
p.P647S	ACH-002159	Skin Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.0833
p.P647S	M14	skin	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	632:638	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons