DegronMD

Uniprot ID: O95936

Source protein: Eomesodermin homolog

Source gene: EOMES

Class: DEG_SCF_TRCP1_1

Location: 632:638

E3 ligase: BTRC

DEGRON score: 0.925

ASA_SCORE: 70.4857

COIL: 0.7017

CONS_SCORE: 0.4369

DSS_SCORE: 0.45

HELIX: 0.2677

FCONS_SCORE: 0.9007

RIG_SCORE: 0.704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S630F	TCGA-A5-A0G1	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	0.2778
p.L645M	TCGA-AP-A051	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	0.1389
p.S627Y	TCGA-E6-A1LX	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	0.6389
p.S630P	TCGA-EO-A22X	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	0.2778
p.S627F	TCGA-EY-A1G8	UCEC	TCGA	DSGVYTS	DEG_SCF_TRCP1_1	0.6389
p.E631G	SIDM01045	Endometrial Carcinoma	GDSC	DSGVYTS	DEG_SCF_TRCP1_1	0.3056
p.E631G	EN	endometrium	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	0.3056
p.R644W	ACH-000986	Colon/Colorectal Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	0.1667
p.R644W	HT-115	large_intestine	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	0.1667
p.A639D	ACH-000996	Endometrial/Uterine Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	0.3056
p.P647S	ACH-002159	Skin Cancer	CCLE	DSGVYTS	DEG_SCF_TRCP1_1	0.0833
p.P647S	M14	skin	COSMIC	DSGVYTS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95936	Eomesodermin homolog	DEG_SCF_TRCP1_1	632:638	DSGVYTS	BTRC	0.925	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons