DegronMD - O95990(FAM107A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P122T	TCGA-37-A5EL	LUSC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.P122T	DO223718	LUSC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.R132W	TCGA-AA-3984	COAD	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7523
p.R132W	TCGA-DF-A2KU	UCEC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7523
p.R132W	DO9002	COAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7523
p.R132W	DO223286	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7523
p.A135V	TCGA-DF-A2KN	UCEC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.5825
p.A135V	DO223282	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.5825
p.E140K	TCGA-FW-A3R5	SKCM	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.E140K	TCGA-HU-A4GN	STAD	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.E140K	DO37406	SKCM	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.E140K	DO47833	STAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1944
p.R127S	DO229058	LICA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7427
p.S125F	DO222434	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2778
p.S125F	DO37851	SKCM	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2778
p.E129K	DO222875	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.591
p.E129K	DO222880	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.591
p.RE127RK	DO222843	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation altering degron motif	0.7237
p.T119M	DO222351	STAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1111
p.G123W	DO42312	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.2222
p.T119A	DO41584	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1111
p.R119W	ACH-000458	Skin Cancer	CCLE	VRENLRRIA	DEG_APCC_DBOX_1	127:135	Mutation rewiring degron network	0.1111

Kaplan plot for FAM107A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM107A

UniProt ID: O95990

Entrez ID: 11170

Protein name: Actin-associated protein FAM107A (Down-regulated in renal cell carcinoma 1) (Protein TU3A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM107A in