DegronMD

Uniprot ID: O95990

Source protein: Actin-associated protein FAM107A

Source gene: FAM107A

Class: DEG_APCC_DBOX_1

Location: 127:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8621

ASA_SCORE: 78.7889

COIL: 0.3283

CONS_SCORE: 0.4905

DSS_SCORE: 0.3913

HELIX: 0.635

FCONS_SCORE: 1.1219

RIG_SCORE: 0.7956

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P122T	TCGA-37-A5EL	LUSC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.P122T	DO223718	LUSC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.R132W	TCGA-AA-3984	COAD	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.7523
p.R132W	TCGA-DF-A2KU	UCEC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.7523
p.R132W	DO9002	COAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.7523
p.R132W	DO223286	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.7523
p.A135V	TCGA-DF-A2KN	UCEC	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.5825
p.A135V	DO223282	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.5825
p.E140K	TCGA-FW-A3R5	SKCM	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.E140K	TCGA-HU-A4GN	STAD	TCGA	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.E140K	DO37406	SKCM	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.E140K	DO47833	STAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.1944
p.R127S	DO229058	LICA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.7427
p.S125F	DO222434	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.2778
p.S125F	DO37851	SKCM	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.2778
p.E129K	DO222875	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.591
p.E129K	DO222880	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.591
p.RE127RK	DO222843	MELA	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.7237
p.T119M	DO222351	STAD	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.1111
p.G123W	DO42312	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.2222
p.T119A	DO41584	UCEC	ICGC	VRENLRRIA	DEG_APCC_DBOX_1	0.1111
p.R119W	ACH-000458	Skin Cancer	CCLE	VRENLRRIA	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95990	Actin-associated protein FAM107A	DEG_APCC_DBOX_1	127:135	VRENLRRIA	APC,CDC20,FZR1	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons