DegronMD - P00390(GSR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R522C	TCGA-06-5416	GBM	TCGA	TLR	DEG_APCC_TPR_1	520:522	Mutation altering degron motif	0.8301
p.R522C	DO10880	GBM	ICGC	TLR	DEG_APCC_TPR_1	520:522	Mutation altering degron motif	0.8301
p.R522C	ACH-000923	Lymphoma	CCLE	TLR	DEG_APCC_TPR_1	520:522	Mutation altering degron motif	0.8301
p.P512T	TCGA-EE-A17Z	SKCM	TCGA	TLR	DEG_APCC_TPR_1	520:522	Mutation rewiring degron network	0.1111
p.P512T	DO37921	SKCM	ICGC	TLR	DEG_APCC_TPR_1	520:522	Mutation rewiring degron network	0.1111
p.P512H	TCGA-ER-A19B	SKCM	TCGA	TLR	DEG_APCC_TPR_1	520:522	Mutation rewiring degron network	0.1111
p.P512H	DO47491	SKCM	ICGC	TLR	DEG_APCC_TPR_1	520:522	Mutation rewiring degron network	0.1111
p.S514P	TCGA-UZ-A9Q1	KIRP	TCGA	TLR	DEG_APCC_TPR_1	520:522	Mutation blocking phosphorylation signal	0.6111
p.S514P	DO219716	KIRP	ICGC	TLR	DEG_APCC_TPR_1	520:522	Mutation blocking phosphorylation signal	0.6111
p.V519F	DO23488	LINC	ICGC	TLR	DEG_APCC_TPR_1	520:522	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons