DegronMD

Uniprot ID: P00390

Source protein: Glutathione reductase, mitochondrial

Source gene: GSR

Class: DEG_APCC_TPR_1

Location: 520:522

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8484

ASA_SCORE: 91.2333

COIL: 0.819

CONS_SCORE: 0.5434

DSS_SCORE: 0.8811

HELIX: 0.157

FCONS_SCORE: 0.7953

RIG_SCORE: 0.8226

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R522C	TCGA-06-5416	GBM	TCGA	TLR	DEG_APCC_TPR_1	0.8301
p.R522C	DO10880	GBM	ICGC	TLR	DEG_APCC_TPR_1	0.8301
p.R522C	ACH-000923	Lymphoma	CCLE	TLR	DEG_APCC_TPR_1	0.8301
p.P512T	TCGA-EE-A17Z	SKCM	TCGA	TLR	DEG_APCC_TPR_1	0.1111
p.P512T	DO37921	SKCM	ICGC	TLR	DEG_APCC_TPR_1	0.1111
p.P512H	TCGA-ER-A19B	SKCM	TCGA	TLR	DEG_APCC_TPR_1	0.1111
p.P512H	DO47491	SKCM	ICGC	TLR	DEG_APCC_TPR_1	0.1111
p.S514P	TCGA-UZ-A9Q1	KIRP	TCGA	TLR	DEG_APCC_TPR_1	0.6111
p.S514P	DO219716	KIRP	ICGC	TLR	DEG_APCC_TPR_1	0.6111
p.V519F	DO23488	LINC	ICGC	TLR	DEG_APCC_TPR_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00390	Glutathione reductase, mitochondrial	DEG_APCC_TPR_1	520:522	TLR	APC,CDC20,FZR1	0.8484	More...
Q3SY05	Putative uncharacterized protein encoded by LINC00303	DEG_APCC_TPR_1	126:128	TLR	APC,CDC20,FZR1	0.6617	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons