DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
TLR
Uniprot ID:
Q3SY05
Source protein:
Putative uncharacterized protein encoded by LINC00303
Source gene:
LINC00303
Class:
DEG_APCC_TPR_1
Location:
126:128
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6617
ASA_SCORE:
140.1
COIL:
0.8643
CONS_SCORE:
0
DSS_SCORE:
0.9525
HELIX:
0.154
FCONS_SCORE:
0
RIG_SCORE:
0.7122
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with LINC00303 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of TLR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P00390
Glutathione reductase, mitochondrial
DEG_APCC_TPR_1
520:522
TLR
APC,CDC20,FZR1
0.8484
More...
Q3SY05
Putative uncharacterized protein encoded by LINC00303
DEG_APCC_TPR_1
126:128
TLR
APC,CDC20,FZR1
0.6617
More...