DegronMD - P00450(CP)

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K421T	TCGA-A5-A2K5	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.7306
p.K421T	DO41379	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.7306
p.D430Y	TCGA-AX-A2HC	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.25
p.D430Y	DO41572	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.25
p.T414I	TCGA-DF-A2KU	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1389
p.T414I	DO223286	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1389
p.R415I	TCGA-EO-A22R	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1667
p.R415I	DO42713	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1667
p.K422E	TCGA-EO-A22U	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.591
p.K422E	DO43755	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.591
p.R436Q	TCGA-F4-6807	COAD	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.0833
p.R436Q	DO9716	COAD	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.0833
p.R426S	TCGA-KQ-A41N	BLCA	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6316
p.R426S	DO223588	BLCA	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6316
p.K437E	SIDM00699	Small Cell Lung Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation substituting flanking lysine	0.1667
p.K437E	ACH-001138	Lung Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation substituting flanking lysine	0.1667
p.K437E	NCI-H2141	lung	COSMIC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation substituting flanking lysine	0.1667
p.R415K	SIDM00118	Colorectal Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1667
p.R415K	ACH-001081	Colon/Colorectal Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1667
p.R415K	HCC2998	large intestine	COSMIC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation rewiring degron network	0.1667
p.K422T	SIDM01588	Endometrial Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6195
p.K422T	ACH-000993	Endometrial/Uterine Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	421:427	Mutation altering degron motif	0.6195

Kaplan plot for CP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CP

UniProt ID: P00450

Entrez ID: 1356

Protein name: Ceruloplasmin (EC 1.16.3.1) (Ferroxidase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CP in