DegronMD

Uniprot ID: P00450

Source protein: Ceruloplasmin

Source gene: CP

Class: LIG_APCC_ABBAyCdc20_2

Location: 421:427

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7189

ASA_SCORE: 60.5429

COIL: 0.2576

CONS_SCORE: 0.6786

DSS_SCORE: 0.2643

HELIX: 0.0169

FCONS_SCORE: 1.0969

RIG_SCORE: 0.8596

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K421T	TCGA-A5-A2K5	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.7306
p.K421T	DO41379	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.7306
p.D430Y	TCGA-AX-A2HC	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.D430Y	DO41572	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.25
p.T414I	TCGA-DF-A2KU	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.T414I	DO223286	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R415I	TCGA-EO-A22R	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R415I	DO42713	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K422E	TCGA-EO-A22U	UCEC	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.591
p.K422E	DO43755	UCEC	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.591
p.R436Q	TCGA-F4-6807	COAD	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R436Q	DO9716	COAD	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.R426S	TCGA-KQ-A41N	BLCA	TCGA	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.6316
p.R426S	DO223588	BLCA	ICGC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.6316
p.K437E	SIDM00699	Small Cell Lung Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K437E	ACH-001138	Lung Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K437E	NCI-H2141	lung	COSMIC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R415K	SIDM00118	Colorectal Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R415K	ACH-001081	Colon/Colorectal Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R415K	HCC2998	large_intestine	COSMIC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.K422T	SIDM01588	Endometrial Carcinoma	GDSC	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.6195
p.K422T	ACH-000993	Endometrial/Uterine Cancer	CCLE	KKLVYRE	LIG_APCC_ABBAyCdc20_2	0.6195

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00450	Ceruloplasmin	LIG_APCC_ABBAyCdc20_2	421:427	KKLVYRE	APC,CDC20,FZR1	0.7189	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons