DegronMD - P00734(F2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R198C	TCGA-24-1104	OV	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198C	TCGA-DI-A1BU	UCEC	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198C	DO31909	OV	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198C	DO42023	UCEC	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198C	SIDM00875	Breast Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198C	ACH-000624	Breast Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.719
p.R198L	TCGA-95-7043	LUAD	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7316
p.R198L	DO24739	LUAD	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7316
p.G187V	TCGA-A5-A0G2	UCEC	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.1667
p.G187V	DO41235	UCEC	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.1667
p.G201D	TCGA-D3-A1QB	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.3056
p.G201D	DO47573	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.3056
p.V193E	TCGA-D3-A8GL	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7693
p.V193E	DO50287	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7693
p.S199F	TCGA-EE-A2MS	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7982
p.S199F	DO37567	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7982
p.G201C	TCGA-HU-A4GN	STAD	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.3056
p.G201C	DO47833	STAD	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.3056
p.G201V	DO229036	LICA	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.3056
p.P197Q	DO229257	THCA	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7035
p.S202F	SIDM01175	Other Sarcomas	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2778
p.S202F	ACH-002309	Sarcoma	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2778
p.S202F	SW684	soft tissue	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2778
p.E200K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation altering degron motif	0.7022
p.D189N	SIDM00683	Prostate Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2222
p.D189N	ACH-000977	lymph node	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2222
p.D189N	LNCaP-Clone-FGC	prostate	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.2222
p.S203N	SIDM00276	Biliary Tract Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.25
p.S203N	ACH-001858	Bile Duct Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.25
p.S203N	ACH-002237	Bile Duct Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.25
p.S203N	ETK-1	biliary tract	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	193:200	Mutation rewiring degron network	0.25

Kaplan plot for F2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

F2

UniProt ID: P00734

Entrez ID: 2147

Protein name: Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for F2 in