DegronMD

Uniprot ID: P00734

Source protein: Prothrombin

Source gene: F2

Class: DEG_SCF_FBW7_2

Location: 193:200

E3 ligase: FBXW7

DEGRON score: 0.9257

ASA_SCORE: 70.0125

COIL: 0.6731

CONS_SCORE: 0.3709

DSS_SCORE: 0.528

HELIX: 0.0806

FCONS_SCORE: 0.9096

RIG_SCORE: 0.7104

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R198C	TCGA-24-1104	OV	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198C	TCGA-DI-A1BU	UCEC	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198C	DO31909	OV	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198C	DO42023	UCEC	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198C	SIDM00875	Breast Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198C	ACH-000624	Breast Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	0.719
p.R198L	TCGA-95-7043	LUAD	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.7316
p.R198L	DO24739	LUAD	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.7316
p.G187V	TCGA-A5-A0G2	UCEC	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.1667
p.G187V	DO41235	UCEC	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.1667
p.G201D	TCGA-D3-A1QB	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.3056
p.G201D	DO47573	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.3056
p.V193E	TCGA-D3-A8GL	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.7693
p.V193E	DO50287	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.7693
p.S199F	TCGA-EE-A2MS	SKCM	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.7982
p.S199F	DO37567	SKCM	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.7982
p.G201C	TCGA-HU-A4GN	STAD	TCGA	VAMTPRSE	DEG_SCF_FBW7_2	0.3056
p.G201C	DO47833	STAD	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.3056
p.G201V	DO229036	LICA	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.3056
p.P197Q	DO229257	THCA	ICGC	VAMTPRSE	DEG_SCF_FBW7_2	0.7035
p.S202F	SIDM01175	Other Sarcomas	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	0.2778
p.S202F	ACH-002309	Sarcoma	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	0.2778
p.S202F	SW684	soft_tissue	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	0.2778
p.E200K	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	0.7022
p.D189N	SIDM00683	Prostate Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	0.2222
p.D189N	ACH-000977	lymph_node	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	0.2222
p.D189N	LNCaP-Clone-FGC	prostate	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	0.2222
p.S203N	SIDM00276	Biliary Tract Carcinoma	GDSC	VAMTPRSE	DEG_SCF_FBW7_2	0.25
p.S203N	ACH-001858	Bile Duct Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	0.25
p.S203N	ACH-002237	Bile Duct Cancer	CCLE	VAMTPRSE	DEG_SCF_FBW7_2	0.25
p.S203N	ETK-1	biliary_tract	COSMIC	VAMTPRSE	DEG_SCF_FBW7_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VAMTPRSE

Degron related mutations and impact score

Drug responses associated with F2 mutations

All proteins holding degron of VAMTPRSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P00734	Prothrombin	DEG_SCF_FBW7_2	193:200	VAMTPRSE	FBXW7	0.9257	More...